转移性化生型乳腺癌采用阿霉素和顺铂治疗获得成功。

Department of Hematology, Okayama City Hospital, Japan.

Department of Oncology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Japan.

Intern Med. 2023 Feb 15;62(4):655-659. doi: 10.2169/internalmedicine.9380-22. Epub 2022 Jul 29.

Metaplastic breast cancer (MBC) is characterized by the histological presence of a mixture of epithelial and mesenchymal-like elements. However, MBC responds poorly to chemotherapy. Due to its rarity, there is no well-defined treatment for MBC. Herein, we report the case of a 56-year-old woman who underwent a mastectomy and was diagnosed with MBC with osseous differentiation classified as pT4N0M1. After the operation, she was treated with adriamycin and cisplatin, which are standard osteosarcoma treatments, resulting in a partial response. However, to determine the proper chemotherapy treatment, knowledge of the metaplastic elements of the tumor is required.

化生性乳腺癌（MBC）的特征是组织学上存在上皮和间叶样成分的混合。然而，MBC 对化疗反应不佳。由于其罕见性，目前尚无针对 MBC 的明确治疗方法。在此，我们报告了一例 56 岁女性患者的病例，该患者接受了乳房切除术，并被诊断为伴有骨分化的 MBC，分类为 pT4N0M1。手术后，她接受了阿霉素和顺铂治疗，这是标准的骨肉瘤治疗方法，结果显示部分缓解。然而，为了确定适当的化疗治疗方案，需要了解肿瘤的化生性成分。