Zhang Shihao, Lin Anqi, Tao Ziwei, Fu Yingying, Xiao Lan, Ruan Guomo, Li Yulin
Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Centre for Biomedical Technologies, Queensland University of Technology, Queensland, 4059, Australia.
Chem Asian J. 2022 Oct 17;17(20):e202200630. doi: 10.1002/asia.202200630. Epub 2022 Aug 16.
Key Laboratory for Ultrafine Materials of Ministry of Education Centre for Biomedical Technologies Current tissue engineering technology aims to achieve the regeneration of human tissues, which integrates the key factors such as scaffolds, cells and biomolecules. Among these key factors, the development of high-performance scaffolds is the basis for the success of tissue engineering strategies. In the past decades, hydrogel scaffolds have been developed rapidly and widely used in biomedical field, however, their drawbacks have also been revealed, which shows that a single hydrogel scaffold cannot meet the excellent performance required in the field of tissue engineering. Recently, microspheres have been further engineered to fabricate structurally and functionally reliable artificial three-dimensional scaffolds of desired shape with enhanced specific biological functions. Therefore, the effective combination of hydrogel and microspheres can facilitate the development of high-performance scaffolds for tissue engineering and further fine-tuning the composite structure, which is expected to solve the dilemma faced by a single scaffold. In this review paper, we systematically summurized the type and preparation method for synthesis of hydrogel and microsphere materials commonly used in developing microsphere-containing hydrogel scaffolds. We then reviewed the broad application of these hybrid scaffolds in various fields of tissue engineering, followed by a summary and perspective on future directions.
教育部超细材料重点实验室 生物医学技术中心 当前的组织工程技术旨在实现人体组织的再生，该技术整合了支架、细胞和生物分子等关键要素。在这些关键要素中，高性能支架的开发是组织工程策略成功的基础。在过去几十年中，水凝胶支架得到了快速发展并广泛应用于生物医学领域，然而，其缺点也已显现，这表明单一的水凝胶支架无法满足组织工程领域所需的优异性能。最近，微球已被进一步设计，以制造具有所需形状的结构和功能可靠的人工三维支架，并增强特定的生物学功能。因此，水凝胶和微球的有效结合可以促进用于组织工程的高性能支架的开发，并进一步微调复合结构，有望解决单一支架面临的困境。在这篇综述文章中，我们系统地总结了用于开发含微球水凝胶支架的水凝胶和微球材料的合成类型及制备方法。然后，我们综述了这些混合支架在组织工程各个领域的广泛应用，最后对未来方向进行了总结和展望。
