Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, India.
Curr Pharm Des. 2022;28(29):2404-2414. doi: 10.2174/1381612828666220728112741.
Aquasomes are novel trilayered non-lipoidal vesicular nanocarriers that demonstrate structural similarity to ceramic nanoparticles with theranostic activity for diseases like ovarian cancer and antigen delivery.
The objective of the present article is to highlight the multifaceted potential of aquasomes over other nanocarriers for the treatment of various treatments like hemophilia A, cancer, and hepatitis.
Aquasomes enter the target cell by modifying the surface chemistry, extending drug release. The solid core of aquasomes provides structural stability whereas their oligomeric coatings protect drugs from dehydration. This vesicular delivery system was successfully utilized for the delivery of acid-labile enzymes, antigens, vaccines, etc. The aquasomes nanocarrier exhibits a larger surface area, volume, and mass ratio that allows the drug to penetrate inside the cells and a prolonged drug release profile. Moreover, aquasomes consist of a high mechanical strength, reduced or no biodegradability during storage, and a good body response that facilitates deeper penetration into capillaries which makes them more special and interesting.
Aquasomes are a potential alternative over other nanocarriers for insulin, antigen, and oxygen delivery.
In the near future, aquasomes-based nano-drug delivery systems can be a fascinating field for research in nanotechnology.
水通道蛋白是一种新型的三层非脂质囊泡纳米载体，其结构与具有治疗卵巢癌和抗原递呈等疾病的治疗潜力的陶瓷纳米颗粒相似。
本文旨在强调水通道蛋白相对于其他纳米载体在治疗血友病 A、癌症和肝炎等多种疾病方面的多方面潜力。
水通道蛋白通过改变表面化学性质来进入靶细胞，从而延长药物释放时间。水通道蛋白的固体核心提供结构稳定性，而其低聚物涂层则保护药物免受脱水。这种囊泡递药系统已成功用于递送酸不稳定酶、抗原、疫苗等。水通道蛋白纳米载体具有更大的表面积、体积和质量比，使药物能够穿透细胞内部，并具有延长的药物释放曲线。此外，水通道蛋白具有较高的机械强度、在储存过程中减少或没有生物降解性以及良好的身体反应性，这使得它们更容易穿透毛细血管，因此更加特殊和有趣。
水通道蛋白是胰岛素、抗原和氧气输送等其他纳米载体的潜在替代品。
在不久的将来，基于水通道蛋白的纳米药物递送系统可能成为纳米技术研究的一个引人注目的领域。
