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髋关节假体周围股骨骨折的管理和结果:来自假体周围骨折服务评估(COMPOSE)队列研究的特征、结果和管理数据。

Management and outcomes of femoral periprosthetic fractures at the hip : data from the characteristics, outcomes and management of periprosthetic fracture service evaluation (COMPOSE) cohort study.

出版信息

Bone Joint J. 2022 Aug;104-B(8):997-1008. doi: 10.1302/0301-620X.104B8.BJJ-2021-1682.R1.

Abstract

AIMS

The aim of this study was to describe the management and associated outcomes of patients sustaining a femoral hip periprosthetic fracture (PPF) in the UK population.

METHODS

This was a multicentre retrospective cohort study including adult patients who presented to 27 NHS hospitals with 539 new PPFs between 1 January 2018 and 31 December 2018. Data collected included: management strategy (operative and nonoperative), length of stay, discharge destination, and details of post-treatment outcomes (reoperation, readmission, and 30-day and 12-month mortality). Descriptive analysis by fracture type was performed, and predictors of PPF management and outcomes were assessed using mixed-effects logistic regression.

RESULTS

In all, 417 fractures (77%) were managed operatively and 122 (23%) conservatively. The median time to surgery was four days (interquartile range (IQR) 2 to 7). Of those undergoing surgery, 246 (59%) underwent revision and/or fixation and 169 (41%) fixation alone. The surgical strategy used differed by Unified Classification System for PPF type, with the highest rate of revision in B2/B3 fractures (both 77%, 176/228 and 24/31, respectively) and the highest rate of fixation alone in B1- (55/78; 71%) and C-type (49/65; 75%) fractures. Cemented stem fixation (odds ratio (OR) 2.66 (95% confidence interval (CI) 1.42 to 4.99); p = 0.002) and B2/B3 fracture type (OR 7.56 (95% CI 4.14 to 13.78); p < 0.001) were predictors of operative management. The median length of stay was 15 days (IQR 9 to 23), 12-month reoperation rate was 5.6% (n = 30), and 30-day readmission rate was 8.4% (n = 45). The 30-day and 12-month mortality rates were 5.2% (n = 28) and 21.0% (n = 113). Nonoperative treatment, older age, male sex, admission from residential or nursing care, and sustaining the PPF around a revision prosthesis were significant predictors of an increased 12-month mortality.

CONCLUSION

Femoral hip PPFs have mortality, reoperation, and readmission rates comparable with hip fracture patients. However, they have a longer wait for surgery, and surgical treatment is more complex. There is a need to create a national framework for data collection for this heterogeneous group of patients in order to understand the outcomes of different approaches to treatment. Cite this article:  2022;104-B(8):997-1008 .

摘要

目的

本研究旨在描述英国人群中股骨髋关节假体周围骨折(PPF)患者的管理和相关结局。

方法

这是一项多中心回顾性队列研究,纳入了 2018 年 1 月 1 日至 2018 年 12 月 31 日期间在 27 家 NHS 医院就诊的 539 例新发生的 PPF 成年患者。收集的数据包括:管理策略(手术和非手术)、住院时间、出院去向以及治疗后结局(再次手术、再入院和 30 天和 12 个月死亡率)的详细信息。按骨折类型进行描述性分析,并使用混合效应逻辑回归评估 PPF 管理和结局的预测因素。

结果

总共 417 例(77%)骨折采用手术治疗,122 例(23%)采用保守治疗。手术时间中位数为 4 天(四分位距(IQR)2-7)。接受手术治疗的患者中,246 例行翻修和/或固定术(59%),169 例行单纯固定术(41%)。根据 PPF 统一分类系统,使用的手术策略有所不同,B2/B3 型骨折的翻修率最高(均为 77%,176/228 和 24/31),B1-和 C 型骨折的单纯固定率最高(分别为 55/78;71%和 49/65;75%)。骨水泥固定(比值比(OR)2.66(95%置信区间(CI)1.42-4.99);p = 0.002)和 B2/B3 骨折类型(OR 7.56(95%CI 4.14-13.78);p<0.001)是手术治疗的预测因素。住院时间中位数为 15 天(IQR 9-23),12 个月再手术率为 5.6%(n = 30),30 天再入院率为 8.4%(n = 45)。30 天和 12 个月的死亡率分别为 5.2%(n = 28)和 21.0%(n = 113)。非手术治疗、年龄较大、男性、从居住或护理院入院以及在翻修假体周围发生 PPF,是 12 个月死亡率增加的显著预测因素。

结论

股骨髋关节 PPF 的死亡率、再次手术率和再入院率与髋关节骨折患者相当。然而,他们需要等待更长的时间才能接受手术,并且手术治疗更为复杂。需要为这组异质性患者创建一个全国性的数据收集框架,以了解不同治疗方法的结局。

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