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黏液性交界性卵巢肿瘤:萨拉赫·阿扎伊兹研究所的病理和预后研究。

Mucinous borderline ovarian tumors: pathological and prognostic study at Salah Azaiez Institute.

机构信息

Pathology Department, Salah Azaiez Institute, Tunis, Tunisia.

Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

出版信息

Pan Afr Med J. 2022 Apr 29;41:349. doi: 10.11604/pamj.2022.41.349.32332. eCollection 2022.

Abstract

INTRODUCTION

ovarian Mucinous Borderline Tumors (MBT) are characterized by an epithelial proliferation similar to those of well differentiated adenocarcinomas but are distinguished by the absence of stromal invasion. They are often difficult to diagnose histologically. The aim of the work was to specify the pathological and clinical features and to highlight the prognostic of these tumors.

METHODS

study was retrospective including 49 cases of primary ovarian MBT, diagnosed at the Patholgy Department of Salah Azaiez Institute from 1992 to 2019.

RESULTS

median age was 48 years old. Histologically, the cases were divided into 34 cases of pure MBT, 13 cases with intraepithelial carcinoma and 2 cases associating an intraepithelial carcinoma with microinvasion. The majority of our cases were classified FIGO I and only one case FIGO III. Sixteen patients received conservative treatment and 30 received radical treatment. The treatment wasn't specified in three patients. The prognosis was good in the majority of cases. Only one patient had a contralateral recurrence after a follow-up period of three years. There were no significant differences regarding the risk of recurrence and risk factors such as age, gestation, hormonal status, FIGO stage and conservative treatment. We raised this part.

CONCLUSION

the prognosis of the ovarian MBT is good. However, it is necessary to multiply the samples to avoid missing a carcinomatous focus with an anarchic invasion of the stroma which constitutes a poor prognosis factor. It was changed by these sentences below: the diagnosis of MBT is not easy. Indeed, the distinction of MBT from carcinomas remains the greatest challenge for pathologists. Once this diagnosis is made with certainty, the tumor can be considered to have a good prognosis, especially stage I tumors which are the most common.

摘要

简介

卵巢黏液性交界性肿瘤(MBT)的特点是上皮增生类似于分化良好的腺癌,但没有间质浸润。它们在组织学上常常难以诊断。本研究的目的是明确这些肿瘤的病理和临床特征,并强调其预后。

方法

本研究回顾性分析了 1992 年至 2019 年在 Salah Azaiez 研究所病理科诊断的 49 例原发性卵巢 MBT 病例。

结果

中位年龄为 48 岁。组织学上,病例分为 34 例单纯 MBT、13 例伴上皮内癌和 2 例伴上皮内癌伴微浸润。我们的大多数病例被分类为 FIGO I 期,只有 1 例为 FIGO III 期。16 例患者接受了保守治疗,30 例患者接受了根治性治疗。3 例患者的治疗方案未明确。大多数患者预后良好。仅 1 例患者在随访 3 年后出现对侧复发。复发风险和危险因素(如年龄、妊娠、激素状态、FIGO 分期和保守治疗)无显著差异。我们提出了这部分内容。

结论

卵巢 MBT 的预后良好。然而,有必要增加样本量,以避免遗漏具有无序侵袭间质的癌灶,因为这是预后不良的因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a26/9279460/40a059a83fad/PAMJ-41-349-g001.jpg

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