Melikov E M
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Mar-Apr;37(2):246-53.
In adult male cats with chronically implanted electrodes and canules, serotonin (5-OT) microapplication in doses of 15-30 mkg bilaterally in the dorsal hippocampus, elicited a change of temporal characteristics of slow-wave (SWS) and paradoxical (PS) sleep and intensified phasic reactions. At doses of 30 mkg, 5-OT in the SWS stage produced periods of somnambulistic forms of behaviour, turning sometimes in real awakening. Microapplication of noradrenaline (NA) in the dorsal hippocampus in doses of 15-30 mkg elicited changes of temporal characteristics of SWS and PS and inhibited phasic reactions. Large doses (30 mkg) of NA, in PS phase elicited fragments of SWS. In the PS stage 5-OT caused dominance of 6.5 Hz frequency of the theta-rhythm of the hippocampus, NA in small doses (15 mkg) in the PS phase led to theta-rhythm dominance at the 4-5 Hz frequency. It is suggested that the hippocampus and its monoaminoreactive systems participate in central mechanisms of PS phasic type.
在长期植入电极和插管的成年雄性猫中，双侧背侧海马体微量注射15 - 30微克的血清素（5 - OT），会引起慢波睡眠（SWS）和异相睡眠（PS）的时间特征变化，并增强相位反应。在30微克的剂量下，SWS阶段的5 - OT会产生梦游行为期，有时会转变为真正的觉醒。在背侧海马体中微量注射15 - 30微克的去甲肾上腺素（NA），会引起SWS和PS的时间特征变化，并抑制相位反应。大剂量（30微克）的NA在PS期会引发SWS片段。在PS阶段，5 - OT导致海马体θ节律的6.5赫兹频率占主导，PS期小剂量（15微克）的NA会导致4 - 5赫兹频率的θ节律占主导。提示海马体及其单胺反应系统参与PS相位型的中枢机制。
