Singh Ashutosh Kumar, Khanal Nikita, Chaulagain Rajib
Department of Oral and Maxillofacial Surgery, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu, Nepal.
Ek Ek Paila Foundation, Kathmandu, Nepal.
Int J Dent. 2022 Jul 22;2022:9696378. doi: 10.1155/2022/9696378. eCollection 2022.
Advances in tissue engineering have progressed to potentially offer a solution to temporomandibular joint disc (TMJ) disorders not amenable to conservative therapies. Conclusive treatment options for patients with end-stage disc disorders requires discectomy and reconstruction of the articular disc with various materials. Tissue engineering TMJ disc is a promising alternative to the limited and sometimes inadequate clinical options in the management of such disorders. However, tissue engineering is far from completion for the TMJ disc regeneration. This review briefly discusses the properties of native disc, the mechanism by which TMJ disorders manifest, and how a tissue engineered disc could assuage the problems inherent in the management of such disorders. Furthermore, the review addresses and provides updates to relevant themes of tissue engineering in regards to the TMJ disc, namely, the scaffolds, cells and biomarkers, hurdles in tissue engineering of the disc, and its application in translation to the clinical practice and future directions.
组织工程学的进展已发展到有可能为颞下颌关节盘（TMJ）紊乱提供解决方案，这些紊乱对保守治疗无效。对于终末期关节盘紊乱患者，确定性的治疗选择需要进行椎间盘切除术并用各种材料重建关节盘。组织工程颞下颌关节盘是管理此类紊乱时有限且有时不足的临床选择的一种有前景的替代方案。然而，对于颞下颌关节盘再生而言，组织工程学远未完成。本综述简要讨论了天然关节盘的特性、颞下颌关节紊乱的表现机制，以及组织工程关节盘如何缓解此类紊乱管理中固有的问题。此外，该综述阐述并更新了与颞下颌关节盘相关的组织工程学主题，即支架、细胞和生物标志物、关节盘组织工程中的障碍，以及其在转化为临床实践和未来方向方面的应用。
