Master of Science Program in Orofacial Pain and Oral Medicine, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, USA.
Division of Periodontology, Diagnostic Sciences & Dental Hygiene, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, USA.
J Tissue Eng Regen Med. 2022 Jul;16(7):591-604. doi: 10.1002/term.3302. Epub 2022 Mar 31.
Temporomandibular joint disorders (TMDs) range from gross anatomic deformities of the disc and hard tissue to functional disturbances. Traditional treatment of TMDs includes physical therapy, use of appliances, pharmacological, surgical and psychological interventions. However, during the late stage of TMDs, conventional management often results in inadequate relief of symptoms. Stem cell-based tissue regeneration has been studied extensively in joint regeneration, including the Temporomandibular Joint (TMJ). This study aims to review the potential of various human stem cells (HSC) for the regeneration of the TMJ. In vitro studies using human mesenchymal stem cells cultured under different conditions to evaluate regeneration of TMJ related structures were searched on PubMed, EMBASE, Cochrane, and Web of Science up to March 2020. In vitro studies utilized several different types of stem cells under varying conditions. Increased osteogenesis and/or chondrogenesis were noted with stem cell interventions compared to control groups on Alkaline Phosphatase (ALP) activity, Col-I, Col-II, Col-X, RUNX2, LPL, and Aggrecan mRNA expression. This review emphasizes the potential of stem cell therapies in the regeneration of TMJ-related structures. However, further in vivo studies are required to evaluate the efficacy and safety of these therapies in humans.
颞下颌关节紊乱（TMDs）的范围从盘状和硬组织的大体解剖畸形到功能障碍。TMDs 的传统治疗包括物理治疗、器械使用、药理学、手术和心理干预。然而，在 TMDs 的晚期，常规治疗往往导致症状缓解不足。基于干细胞的组织再生在关节再生中得到了广泛研究，包括颞下颌关节（TMJ）。本研究旨在综述各种人类干细胞（HSC）在 TMJ 再生中的潜力。在 2020 年 3 月之前，我们在 PubMed、EMBASE、Cochrane 和 Web of Science 上搜索了使用不同条件培养的人骨髓间充质干细胞进行 TMJ 相关结构再生的体外研究。体外研究在不同条件下使用了几种不同类型的干细胞。与对照组相比，干细胞干预后碱性磷酸酶（ALP）活性、Col-I、Col-II、Col-X、RUNX2、LPL 和 Aggrecan mRNA 表达增加，骨生成和/或软骨生成增加。本综述强调了干细胞疗法在 TMJ 相关结构再生中的潜力。然而，需要进一步的体内研究来评估这些疗法在人类中的疗效和安全性。
