Kenny David, Sleator Roy D, Murphy Craig P, Evans Ross D, Berry Donagh P
Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Co. Cork, Ireland.
Department of Biological Sciences, Munster Technological University, Bishopstown Campus, Co. Cork, Ireland.
Front Genet. 2022 Jul 15;13:951087. doi: 10.3389/fgene.2022.951087. eCollection 2022.
Genomic imprinting is an epigenetic phenomenon defined as the silencing of an allele, at least partially, at a given locus based on the sex of the transmitting parent. The objective of the present study was to detect the presence of SNP-phenotype imprinting associations for carcass weight (), carcass conformation () and carcass fat () in cattle. The data used comprised carcass data, along with imputed, high-density genotype data on 618,837 single nucleotide polymorphisms () from 23,687 cattle; all animal genotypes were phased with respect to parent of origin. Based on the phased genotypes and a series of single-locus linear models, 24, 339, and 316 SNPs demonstrated imprinting associations with CW, CC, and CF, respectively. Regardless of the trait in question, no known imprinted gene was located within 0.5 Mb of the SNPs demonstrating imprinting associations in the present study. Since all imprinting associations detected herein were at novel loci, further investigation of these regions may be warranted. Nonetheless, knowledge of these associations might be useful for improving the accuracy of genomic evaluations for these traits, as well as mate allocations systems to exploit the effects of genomic imprinting.
基因组印记是一种表观遗传现象，定义为基于传递亲本的性别，在给定基因座上至少部分沉默一个等位基因。本研究的目的是检测牛胴体重量（）、胴体形态（）和胴体脂肪（）的单核苷酸多态性-表型印记关联。所使用的数据包括胴体数据，以及来自23687头牛的618837个单核苷酸多态性（）的推算高密度基因型数据；所有动物基因型均根据起源亲本进行了分型。基于分型后的基因型和一系列单基因座线性模型，分别有24个、339个和316个单核苷酸多态性与胴体重量、胴体形态和胴体脂肪表现出印记关联。无论所讨论的性状如何，在本研究中表现出印记关联的单核苷酸多态性的0.5兆碱基范围内均未发现已知的印记基因。由于本文检测到的所有印记关联均位于新的基因座上，因此可能有必要对这些区域进行进一步研究。尽管如此，了解这些关联可能有助于提高这些性状的基因组评估准确性，以及利用基因组印记效应的交配分配系统。
