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肾毛霉菌病:1例新型冠状病毒肺炎后感染,表现为年轻免疫功能正常男性单侧肾积水

Renal Mucormycosis: Post-COVID-19 Infection Presenting as Unilateral Hydronephrosis in a Young Immunocompetent Male.

作者信息

Nepali Rabin, Shrivastav Shreya, Singh Shah Dibya

机构信息

Department of Nephrology and Transplant Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

出版信息

Case Rep Nephrol. 2022 Jul 21;2022:3488031. doi: 10.1155/2022/3488031. eCollection 2022.

Abstract

Mucormycosis is a rare invasive fungal infection with a high mortality rate caused by members of the family Mucoraceae. It mainly affects immunocompromised hosts such as poorly controlled diabetes mellitus, previous solid organ transplant, high-dose steroids, and hematologic malignancy. The most common sites of the disease are rhinocerebral, the skin, the lungs, and the gastrointestinal tract. In this era of COVID-19 infection, there has been a significant rise in invasive mucormycosis predominantly reported from southeast. We present a case of isolated renal mucormycosis in an apparently healthy individual with post-COVID-19 infection presenting as unilateral hydronephrosis. Timely identifying at-risk populations and having a high degree of suspicion with involvement of multidisciplinary teams are of utmost importance to diagnose and treat a rare and fatal infection. Even if there is a long history, antifungal drugs and removal of the source can result in a good outcome.

摘要

毛霉病是一种由毛霉科真菌引起的罕见侵袭性真菌感染,死亡率很高。它主要影响免疫功能低下的宿主,如控制不佳的糖尿病患者、既往实体器官移植受者、大剂量使用类固醇者以及血液系统恶性肿瘤患者。该病最常见的发病部位是鼻脑、皮肤、肺部和胃肠道。在新冠病毒感染的这个时期,主要来自东南部地区的侵袭性毛霉病报告显著增加。我们报告一例新冠病毒感染康复后的看似健康个体发生孤立性肾毛霉病的病例,该病例表现为单侧肾积水。及时识别高危人群并高度怀疑多学科团队参与对于诊断和治疗这种罕见且致命的感染至关重要。即使病史较长,抗真菌药物治疗和去除感染源仍可带来良好的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdfe/9334039/a40b817be9cb/CRIN2022-3488031.001.jpg

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