Al-Taei Omar, Al-Mirza Abdulrahman, Al Kalbani Humaid, Ali Mohammed, Al-Saadi Tariq
College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Department of Ophthalmology, Oman Medical Specialty Board, Muscat, Sultanate of Oman.
J Epilepsy Res. 2022 Jun 30;12(1):27-32. doi: 10.14581/jer.22005. eCollection 2022 Jun.
Patients over the age of 75 are more likely to develop epilepsy than children under the age of 10. Patients of all ages are prescribed anti-epileptic drugs; however, those over the age of 65 are the most typically prescribed group.
This is a retrospective study of geriatric cases admitted to the Neurosurgery Department in Khoula Hospital from January 1, 2016 to December 31, 2019. A medical records of 669 patients were identified. Patients' demographics, risk factors, usage of anti-epileptic drug (AED), type of tumor, tumor location, neuro-vital signs diagnosis, Glasgow coma scale on arrival, treatment types, and length of stay (LOS) were recorded.
The prevalence of AEDs use was 19%. Patients with traumatic brain injury (TBI) were found to have a higher rate of using AEDs (32.1%) followed by patients with oncological and vascular pathologies, respectively (30.1% and 21.6%). There was a significant relationship between the utilization of AEDs among different neurological diseases investigated (<0.05). Patients who received surgical interventions were using AEDs much more than patients with conservative management (=0.001). There was a significant difference in the LOS and the usage of AEDs. Added to that, the results signify a relationship between the intensive care unit (ICU) admission and the utilization of AEDs in which the majority of the patients who were not on AEDs were not admitted to the ICU (<0.05). Phenytoin was the most commonly used AED among different neurosurgical pathologies in the present study (n=110).
AEDs are used as prophylaxis to prevent seizures before most neurosurgical procedures and were commonly prescribed in TBI patients. Phenytoin was found to be the commonest AEDs utilized among the different neurosurgical categories followed by levetiracetam.
75岁以上的患者比10岁以下的儿童更容易患癫痫。所有年龄段的患者都会使用抗癫痫药物；然而，65岁以上的患者是最常被处方用药的群体。
这是一项对2016年1月1日至2019年12月31日在胡拉医院神经外科住院的老年病例的回顾性研究。识别出669例患者的病历。记录患者的人口统计学资料、危险因素、抗癫痫药物（AED）的使用情况、肿瘤类型及位置、神经生命体征诊断、入院时的格拉斯哥昏迷量表评分、治疗类型以及住院时间（LOS）。
AED的使用率为19%。发现创伤性脑损伤（TBI）患者使用AED的比例更高（32.1%），其次分别是患有肿瘤和血管疾病的患者（30.1%和2l.6%）。在所研究的不同神经系统疾病中，AED的使用情况之间存在显著关系（<0.05）。接受手术干预的患者比采用保守治疗的患者更多地使用AED（P = 0.001）。住院时间和AED的使用存在显著差异。此外，结果表明重症监护病房（ICU）入院与AED的使用之间存在关联，即大多数未使用AED的患者未入住ICU（<0.05）。在本研究中，苯妥英是不同神经外科疾病中最常用的AED（n = 110）。
AED被用作大多数神经外科手术前预防癫痫发作的药物，并且在TBI患者中常用。苯妥英被发现在不同神经外科类别中是最常用的AED，其次是左乙拉西坦。
