Wang Jiayu, Zhou Qi, Ding Jinli, Yin Tailang, Ye Peng, Zhang Yan
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, China.
Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China.
Front Physiol. 2022 Jul 13;13:886261. doi: 10.3389/fphys.2022.886261. eCollection 2022.
Protein ubiquitination with general existence in virtually all eukaryotic cells serves as a significant post-translational modification of cellular proteins, which leads to the degradation of proteins via the ubiquitin-proteasome system. Deubiquitinating enzymes (DUBs) can reverse the ubiquitination effect by removing the ubiquitin chain from the target protein. Together, these two processes participate in regulating protein stability, function, and localization, thus modulating cell cycle, DNA repair, autophagy, and transcription regulation. Accumulating evidence indicates that the ubiquitination/deubiquitination system regulates reproductive processes, including the cell cycle, oocyte maturation, oocyte-sperm binding, and early embryonic development, primarily by regulating protein stability. This review summarizes the extensive research concerning the role of ubiquitin and DUBs in gametogenesis and early embryonic development, which helps us to understand human pregnancy further.
蛋白质泛素化几乎存在于所有真核细胞中，是一种重要的细胞蛋白质翻译后修饰，可通过泛素-蛋白酶体系统导致蛋白质降解。去泛素化酶（DUBs）可以通过从靶蛋白上去除泛素链来逆转泛素化作用。这两个过程共同参与调节蛋白质的稳定性、功能和定位，从而调节细胞周期、DNA修复、自噬和转录调控。越来越多的证据表明，泛素化/去泛素化系统主要通过调节蛋白质稳定性来调节生殖过程，包括细胞周期、卵母细胞成熟、卵母细胞-精子结合和早期胚胎发育。本文综述了关于泛素和DUBs在配子发生和早期胚胎发育中作用的广泛研究，这有助于我们进一步了解人类妊娠。
