[用纯化浓缩葡萄球菌类毒素进行疫苗接种时免疫系统的抗原特异性和非特异性反应]

[Antigen-specific and antigen-nonspecific reactions of the immunity system in vaccination with a purified concentrated staphylococcal anatoxin].

作者信息

Katkhanov A M, Borovikov O V, Prokhorov V Ia, Ratgauz G L, Vasil'eva I V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1987 Mar(3):34-8.

Abstract

Immunization with purified and concentrated staphylococcal toxoid leads to the rapid 12-fold rise of the level of anti-alpha-toxin and to the 17-fold rise of the titres of antibodies to extracellular staphylococcal products. At the period of immunization phasic changes in cell-mediated and humoral immunity characteristics, indicative of the state of the nonspecific resistance system, can be observed. These changes consist in the transient suppression of phagocytosis, including a decrease in the activity of intraleukocytic bactericidal systems (myeloperoxidase and cation protein), a decrease in the activity of the complement and the bactericidal activity of the blood serum, which should be taken into account when using this immune preparation for therapy.

摘要

用纯化浓缩的葡萄球菌类毒素进行免疫接种会导致抗α毒素水平迅速升高12倍，以及针对葡萄球菌细胞外产物的抗体效价升高17倍。在免疫接种期间，可以观察到细胞介导免疫和体液免疫特征的阶段性变化，这表明非特异性抵抗系统的状态。这些变化包括吞噬作用的短暂抑制，包括白细胞内杀菌系统（髓过氧化物酶和阳离子蛋白）活性的降低、补体活性的降低以及血清的杀菌活性降低，在将这种免疫制剂用于治疗时应考虑到这些情况。