Mayer Juliane, Vasic Nenad, Wolf Viviane, Steiner Ivonne, Klein Verena, Fritz Michael, Rothe Philipp, Streb Judith, Dudeck Manuela
Department of Forensic Psychiatry and Psychotherapy, kbo-Isar-Amper-Clinic Taufkirchen (Vils), Taufkirchen, Germany.
Clinic for Psychiatry and Psychotherapy, Clinic Centre Christophsbad, Göppingen, Germany.
Front Psychiatry. 2022 Jul 15;13:907123. doi: 10.3389/fpsyt.2022.907123. eCollection 2022.
In forensic psychiatry, psychopharmacological treatment plays a crucial role for patients with schizophrenia in improving their medical as well as legal prognosis. However, an increase in the number of females entering forensic treatment has yet to yield empirical research on the outcome of psychopharmacological treatment of female patients with schizophrenia in terms of efficacy and tolerability.
The aim of the present study is to elucidate pharmacological treatment strategies of women with schizophrenia in forensic psychiatry in comparison with men.
This study compares psychopharmacological treatment strategies, psychopathological features, as well as neurological and metabolic side effects of treatment between 29 female and 29 male in-patients with schizophrenia in three forensic facilities in Bavaria, Germany.
Results show significant differences between genders. Poorer psychopathological and neurological features were found in the female sample, while men registered worse metabolic parameters. In terms of psychopharmacological treatment strategies, female in-patients were more often prescribed second-generation depot antipsychotics. Surprisingly, the potency of the dosages did not differ between genders. The results suggest that female forensic patients with schizophrenia have more severe and refractory diseases than their male counterparts.
Recommendations for gender-specific treatment strategies are derived.
在法医精神病学中，精神药物治疗对于精神分裂症患者改善其医学及法律预后起着关键作用。然而，进入法医治疗的女性人数增加，但尚未产生关于女性精神分裂症患者精神药物治疗在疗效和耐受性方面结果的实证研究。
本研究的目的是阐明法医精神病学中女性精神分裂症患者与男性相比的药物治疗策略。
本研究比较了德国巴伐利亚州三个法医机构中29名女性和29名男性精神分裂症住院患者的精神药物治疗策略、精神病理学特征以及治疗的神经和代谢副作用。
结果显示性别之间存在显著差异。在女性样本中发现了较差的精神病理学和神经学特征，而男性的代谢参数更差。在精神药物治疗策略方面，女性住院患者更常被处方第二代长效抗精神病药物。令人惊讶的是，剂量的效力在性别之间没有差异。结果表明，女性法医精神分裂症患者的疾病比男性患者更严重且更难治疗。
得出了针对特定性别的治疗策略建议。
