Mpourazanis George, Konschake Wolfgang, Vogiatzis Romanos, Papalexis Petros, Georgakopoulou Vasiliki E, Ntritsos Georgios, Sklapani Pagona, Trakas Nikolaos
Department of Obstetrics and Gynecology, General Hospital of Ioannina G. Hatzikosta, Ioannina, GRC.
Department of Dermatology, Ernst-Moritz-Arndt Medical University of Greifswald, Greifswald, DEU.
Cureus. 2022 Jun 28;14(6):e26390. doi: 10.7759/cureus.26390. eCollection 2022 Jun.
Actinic keratoses (AKs) are the most common neoplastic lesions and are recognized as a precursor to squamous cell skin cancer. Photodynamic therapy (PDT) is a therapeutic option for multiple AKs in line with field cancerization. The aim of this study was to assess the effectiveness of PDT on patients with AKs using a meta-analysis, in order to evaluate the possible superiority of one treatment over the others. For this purpose, the PubMed, MEDLINE, Scopus, OVID, Science Direct, British Journal of Dermatology, Research Gate, and Embase databases were searched in March 2022. The search terms used were 'photodynamic therapy' and 'actinic keratosis'. We utilized the random-effects meta-analysis model to compare methyl aminolevulinate PDT (MAL-PDT) and the combination of a nanoscale-lipid vesicle formulation with the prodrug 5-aminolevulinic acid (BF-200 ALA) on a complete response (CR) of the lesions. Our meta-analysis indicated that the comparison of BF-200 ALA versus MAL-PDT showed marginally higher CRs than MAL-PDT.
光化性角化病（AKs）是最常见的肿瘤性病变，被认为是皮肤鳞状细胞癌的前驱病变。光动力疗法（PDT）是一种针对符合场癌化的多发性AKs的治疗选择。本研究的目的是通过荟萃分析评估PDT对AKs患者的有效性，以评估一种治疗方法相对于其他方法可能具有的优势。为此，于2022年3月检索了PubMed、MEDLINE、Scopus、OVID、Science Direct、《英国皮肤病学杂志》、Research Gate和Embase数据库。使用的检索词为“光动力疗法”和“光化性角化病”。我们采用随机效应荟萃分析模型，比较了甲基氨基酮戊酸光动力疗法（MAL-PDT）以及纳米级脂质囊泡制剂与前药5-氨基酮戊酸（BF-200 ALA）联合使用对病变完全缓解（CR）的情况。我们的荟萃分析表明，BF-200 ALA与MAL-PDT相比，完全缓解率略高于MAL-PDT。
