Gupta Abhaya, Verma Umesh Pratap, Verma Ajay Kumar, Chaudhary Shyam Chand, Lal Nand, Singh Neetu, Shrivastava Ashutosh, Kant Surya
Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Uttar Pradesh, Lucknow, India.
Department of Respiratory Medicine, King George's Medical University, Uttar Pradesh, Lucknow, India.
Natl J Maxillofac Surg. 2022 Jan-Apr;13(1):44-53. doi: 10.4103/njms.njms_386_21. Epub 2022 Apr 20.
Noncystic fibrosis bronchiectasis (NCFB) is a neglected debilitating condition with scarce epidemiological literature explaining its geographical heterogeneity, especially in lower and middle-income countries. This study aimed to assess and correlate the functional profile of NCFB patients and evaluate the correlation of body mass index (BMI) with several disease variables.
This mixed-method retrospective research study was conducted on 124 radiologically confirmed NCFB patients in terms of various qualitative and quantitative variables.
Restrictive ventilatory defect was the most common type with the preponderance of male former smokers. Mean platelet lymphocyte ratio (PLR; 104.08 ± 73.59) revealed certain degree of systemic inflammatory burden with a slightly higher mean peripheral leukocyte count (10665.19 ± 4268.81 cell/mm) and eosinophilia of >2%. Almost all patients had periodontal disease with a higher prevalence of chronic periodontitis (54.83%). Moderately severe and predominantly cystic radiological type was encountered with 61.2% patients positive for Pseudomonas aeruginosa. Bronchiectasis aetiology comorbidity index (BACI) i.e., 2.34 ± 2.37 represented an intermediate mortality risk in our patients. On basis of BMI, majority were young underweights with poor pulmonary functions while PLR skewed toward overweight patients (nonsignificant > 0.05). Forced expiratory volume/forced vital capacity displayed a negative weak moderately significant correlation with BACI ( = -0.24; = 0.008). Peripheral lymphocyte count demonstrated a weak negative but significant correlation with modified Reiff score ( = -0.20; = 0.023) while serum neutrophil count had a weak negative moderately significant correlation with hemoglobin ( = -0.20; = 0.023).
NCFB bears great heterogeneity with distinct geographical phenotypes and should be correlated thoroughly in terms of peripheral leukocytes count, pulmonary functions, radiology, BMI, and coexisting comorbidities for adequate management.
非囊性纤维化支气管扩张症（NCFB）是一种被忽视的使人衰弱的疾病，关于其地理异质性的流行病学文献稀缺，在低收入和中等收入国家尤其如此。本研究旨在评估NCFB患者的功能特征并进行相关性分析，同时评估体重指数（BMI）与多种疾病变量之间的相关性。
本混合方法回顾性研究针对124例经放射学确诊的NCFB患者，分析了各种定性和定量变量。
限制性通气功能障碍是最常见的类型，男性既往吸烟者占多数。平均血小板淋巴细胞比率（PLR；104.08±73.59）显示出一定程度的全身炎症负担，平均外周白细胞计数略高（10665.19±4268.81细胞/mm），嗜酸性粒细胞增多>2%。几乎所有患者都患有牙周疾病，慢性牙周炎患病率较高（54.83%）。遇到中度严重且以囊性为主的放射学类型，61.2%的患者铜绿假单胞菌检测呈阳性。支气管扩张病因合并症指数（BACI）即2.34±2.37表明我们的患者存在中度死亡风险。基于BMI，大多数患者为年轻体重过轻者，肺功能较差，而PLR倾向于超重患者（无统计学意义，P>0.05）。第一秒用力呼气容积/用力肺活量与BACI呈负弱中度显著相关（r=-0.24；P=0.008）。外周淋巴细胞计数与改良Reiff评分呈弱负但显著相关（r=-0.20；P=0.023），而血清中性粒细胞计数与血红蛋白呈弱负中度显著相关（r=-0.20；P=0.023）。
NCFB具有很大的异质性，存在不同的地理表型，应在外周白细胞计数、肺功能、放射学、BMI和并存合并症方面进行全面相关性分析，以进行充分管理。
