Giordo Roberta, Wehbe Zena, Posadino Anna Maria, Erre Gian Luca, Eid Ali H, Mangoni Arduino A, Pintus Gianfranco
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Vascular Biology Research Centre, Molecular and Clinical Research Institute, University of London, London, United Kingdom.
Front Cell Dev Biol. 2022 Jul 13;10:894305. doi: 10.3389/fcell.2022.894305. eCollection 2022.
There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress such as atherosclerosis, diabetes, obesity, multiple sclerosis, osteoporosis, liver and lung fibrosis. Such discoveries have potential therapeutic implications as a better understanding of the molecular mechanisms underpinning the effects of ncRNAs on critical homeostatic control mechanisms and biochemical pathways might lead to the identification of novel druggable targets. In this context, increasing evidence suggests that several natural compounds can target ncRNAs at different levels and, consequently, influence processes involved in the onset and progression of disease states. The natural phenol resveratrol has been extensively studied for therapeutic purposes in view of its established anti-inflammatory and antioxidant effects, particularly in disease states such as cancer and cardiovascular disease that are associated with human aging. However, increasing and evidence also suggests that resveratrol can directly target various ncRNAs and that this mediates, at least in part, its potential therapeutic effects. This review critically appraises the available evidence regarding the resveratrol-mediated modulation of different ncRNAs in a wide range of disease states characterized by a pro-inflammatory state and oxidative stress, the potential therapeutic applications, and future research directions.
在非编码RNA（ncRNAs）的鉴定及其在多种疾病状态，特别是癌症以及其他以炎症和氧化应激过度为特征的慢性疾病（如动脉粥样硬化、糖尿病、肥胖症、多发性硬化症、骨质疏松症、肝纤维化和肺纤维化）中的病理生理作用方面，已经取得了重大进展，尤其是在过去20年中。这些发现具有潜在的治疗意义，因为更好地理解ncRNAs对关键稳态控制机制和生化途径产生影响的分子机制，可能会导致发现新的可成药靶点。在这种背景下，越来越多的证据表明，几种天然化合物可以在不同水平上靶向ncRNAs，从而影响疾病状态的发生和发展过程。鉴于天然酚类白藜芦醇已确定的抗炎和抗氧化作用，尤其是在与人类衰老相关的癌症和心血管疾病等疾病状态中，人们对其治疗用途进行了广泛研究。然而，越来越多的证据还表明，白藜芦醇可以直接靶向各种ncRNAs，并且这至少部分介导了其潜在的治疗作用。本综述批判性地评估了关于白藜芦醇在以促炎状态和氧化应激为特征的多种疾病状态中介导不同ncRNAs调节的现有证据、潜在的治疗应用以及未来的研究方向。
