Silva Leni Verônica de Oliveira, Hermont Ana Paula, Magnani Isabela Queiroz, Martins Carolina Castro, Borges-Oliveira Ana Cristina
Department of Oral Surgery, Pathology, and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Department of Pediatric Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Spec Care Dentist. 2023 Mar;43(2):184-198. doi: 10.1111/scd.12761. Epub 2022 Aug 1.
To synthesize the oral alterations observed in children with microcephaly associated with congenital Zika virus syndrome (CZS), and to compare the oral alterations of these children to a normotypic healthy controls.
A search was performed in six electronic databases. Observational studies published that reported oral alterations in children with CZS were selected. Two authors independently extracted data, assessed study quality, using the Joanna Briggs Institute Critical Appraisal Checklist tools, and the certainty of evidence, using Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Twenty-one studies were included in this systematic review and meta-analysis. The pooled crude occurrence showed 88% of increased salivation (95%CI: 82%-94%), 83% of biofilm (95%CI: 75%-91%), and 73% of bruxism (95%CI: 52%-95%). Compared to normotypic controls, children with CZS-associated microcephaly had a higher chance to have difficulty in lip sealing (OR: 18.28; 95%CI: 1.42-235.91), inadequate lingual posture at rest (OR: 13.57; 95%CI: 4.24-43.44), and delayed eruption (OR: 12.92; 95%CI: 3.42-48.78), with very low certainty.
There are several oral alterations found among children with CZS-associated microcephaly. They are more prone to present some of these alterations, such as difficulty in lip sealing, although with very low certainty of evidence.
综合观察先天性寨卡病毒综合征（CZS）相关小头畸形患儿的口腔改变，并将这些患儿的口腔改变与正常健康对照进行比较。
在六个电子数据库中进行检索。选取已发表的报告CZS患儿口腔改变的观察性研究。两位作者独立提取数据，使用乔安娜·布里格斯研究所批判性评价清单工具评估研究质量，并使用推荐分级评估、制定和评价（GRADE）方法评估证据的确定性。本系统评价和荟萃分析纳入了21项研究。汇总的粗略发生率显示，流涎增加占88%（95%置信区间：82%-94%），生物膜形成占83%（95%置信区间：75%-91%），磨牙症占73%（95%置信区间：52%-95%）。与正常对照相比，CZS相关小头畸形患儿出现唇闭合困难（比值比：18.28；95%置信区间：1.42-235.91）、静息时舌姿势不当（比值比：13.57；95%置信区间：4.24-43.44）和萌出延迟（比值比：12.9；95%置信区间：3.42-48.78）的可能性更高，证据确定性很低。
在CZS相关小头畸形患儿中发现了几种口腔改变。他们更易出现其中一些改变，如唇闭合困难，尽管证据确定性很低。
