Kales A, Bixler E O, Soldatos C R, Cadieux R J, Manfredi R, Vela-Bueno A
Acta Neurol Scand. 1987 Apr;75(4):223-30. doi: 10.1111/j.1600-0404.1987.tb07924.x.
Sleep and wakefulness patterns in daytime naps of 50 patients with narcolepsy/cataplexy were compared with those of 50 controls. Each subject was monitored polygraphically during 2 one-hour nap periods. A sleep-onset REM period in either of the 2 daytime naps was observed to have a higher diagnostic sensitivity (78%) than an abnormally shortened sleep latency (68%). However, the specificities of a sleep-onset REM period (88%) or abnormally shortened sleep latency (90%) were quite similar. When the occurrence of either a sleep-onset REM period or a shortened sleep latency was evaluated in either of the two naps, the overall sensitivity was increased to 84% while the specificity was decreased only to 80%. The limitations of and indications for the use of testing for sleep and REM latencies in the diagnosis of narcolepsy in clinical practice are discussed.
将50例发作性睡病/猝倒症患者日间小睡的睡眠与觉醒模式，与50名对照者的进行了比较。在2个一小时的小睡期间，对每个受试者进行了多导睡眠监测。观察到在2次日间小睡中的任何一次出现睡眠始发快速眼动期，其诊断敏感性（78%）高于异常缩短的睡眠潜伏期（68%）。然而，睡眠始发快速眼动期（88%）或异常缩短的睡眠潜伏期（90%）的特异性相当相似。当在两次小睡中的任何一次评估睡眠始发快速眼动期或缩短的睡眠潜伏期的出现情况时，总体敏感性提高到84%，而特异性仅降至80%。讨论了在临床实践中使用睡眠和快速眼动潜伏期测试诊断发作性睡病的局限性和适应证。
