Miller A B
Cancer Res. 1978 Nov;38(11 Pt 2):3985-90.
Data on the etiology of hormone-associated cancers are reviewed. Although for breast cancer many risk factors point to the relevance of hormonal factors, findings are not uniform. Evidence points to the importance of dietary factors, and one study appears to confirm an association with high total fat intake. Dietary factors, although possibly mediated through a hormonal mechanism, may eventually be found to play a major role in the etiology of breast cancer. Studies of both endometrial and ovarian cancer also show the importance of hormonally associated factors, although not always in the same way as for breast cancer. In addition, both for these sites and for cancer of the prostate, dietary factors may also be relevant in their etiology. As yet, no direct assessment of the importance of diet has been attempted for these sites, but this could be rewarding.
本文综述了激素相关癌症的病因数据。虽然对于乳腺癌来说，许多风险因素表明激素因素具有相关性，但研究结果并不一致。有证据表明饮食因素很重要，一项研究似乎证实了总脂肪摄入量高与之存在关联。饮食因素虽然可能通过激素机制介导，但最终可能会被发现对乳腺癌的病因起着主要作用。对子宫内膜癌和卵巢癌的研究也表明激素相关因素很重要，尽管其方式并不总是与乳腺癌相同。此外，对于这些部位以及前列腺癌来说，饮食因素在其病因中可能也具有相关性。目前尚未对这些部位饮食的重要性进行直接评估，但这可能会有所收获。
