Ekbom A
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Semin Cancer Biol. 1998 Aug;8(4):237-44. doi: 10.1006/scbi.1998.0073.
Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breast, prostate, and non-seminoma testicular cancer. Indicators of low levels, like pre-eclampsia, are associated with decreased risk. These results support the hypothesis that the pre- and perinatal periods constitute a 'time window' that is of major importance for future cancer risk.
激素相关癌症可能始于子宫内。动物研究、描述性流行病学数据和分析性病因学研究提供了越来越多的证据。内源性妊娠激素水平高的指标，如后代出生体重高和黄疸，与乳腺癌、前列腺癌和非精原细胞瘤性睾丸癌风险增加有关。水平低的指标，如先兆子痫，与风险降低有关。这些结果支持了这样一种假说，即产前和围产期构成了一个对未来癌症风险至关重要的“时间窗”。
