Wu Jian, Du Yifan, Lin Caixia, Du Jianli, Chen Wei, Ji Qian Qian, Wang Ningli
Dongcheng District, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, No. 1 Dong Jiao Min Xiang Street, Beijing, People's Republic of China, 100730.
Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.
Graefes Arch Clin Exp Ophthalmol. 2023 Jan;261(1):201-211. doi: 10.1007/s00417-022-05753-z. Epub 2022 Aug 1.
To evaluate the relationship between retinal nerve fiber layer (RNFL) thickness and other related parameters measured by spectral-domain optical coherence tomography and the refractive error of eyes.
A total of 5394 subjects were enrolled in this population-based cohort study, who were divided into three groups by refractive state after they underwent a standardized ophthalmic examination: emmetropia (the absolute value should range from 0 to 0.5 D), low-moderate myopia (the absolute value of myopic error should range from 0.5 to 6 D), and high myopia (the absolute value of myopic error should be over than 6 D). R 3.6.1 software was adopted for statistical analysis.
Two thousand five hundred fifty-two subjects (4548 eyes) were collected in this study, with an average age of 53.14 ± 10.64 years. There were significant differences among groups in average central corneal curvature, spherical equivalent, and axial length (P < 0.001). The measurements of average retinal nerve fiber layer (RNFL) were 113.95 ± 10.62 μm, 112.97 ± 11.59 μm, and 101.88 ± 15.67 μm, respectively, in the emmetropia, low-moderate, and high myopia groups (P < 0.001). Meanwhile, there was a decreasing trend of cup area, cup volume, disc area, and rim area in the high myopia group compared with the emmetropia group (P < 0.001).
The measurements of RNFL thickness vary greatly with refractive error, and this study indicated that it is of great significance for the accurate diagnosis of glaucoma to establish an individualized RNFL thickness database.
评估通过光谱域光学相干断层扫描测量的视网膜神经纤维层（RNFL）厚度及其他相关参数与眼睛屈光不正之间的关系。
共有5394名受试者纳入了这项基于人群的队列研究，在他们接受标准化眼科检查后，根据屈光状态分为三组：正视眼（绝对值范围应为0至0.5 D）、中低度近视（近视度数绝对值范围应为0.5至6 D）和高度近视（近视度数绝对值应大于6 D）。采用R 3.6.1软件进行统计分析。
本研究共收集了2552名受试者（4548只眼），平均年龄为53.14±10.64岁。各组之间在平均中央角膜曲率、等效球镜度和眼轴长度方面存在显著差异（P<0.001）。正视眼组、中低度近视组和高度近视组的平均视网膜神经纤维层（RNFL）测量值分别为113.95±10.62μm、112.97±11.59μm和101.88±15.67μm（P<0.001）。同时，与正视眼组相比，高度近视组的杯面积、杯容积、视盘面积和盘沿面积呈下降趋势（P<0.001）。
RNFL厚度测量值随屈光不正有很大差异，本研究表明建立个体化的RNFL厚度数据库对青光眼的准确诊断具有重要意义。
