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关于某些生物活性葡聚糖的研究。

Studies on some biologically active dextrans.

作者信息

Preobrazhenskaya M E, Rosenfeld E L, Kandra L

出版信息

Carbohydr Res. 1978 Oct;66:213-23. doi: 10.1016/s0008-6215(00)83254-1.

DOI:10.1016/s0008-6215(00)83254-1
PMID:359138
Abstract

The relationship between the structures of six native dextrans and their effects on nonspecific resistance to infection (n.s.r.i.) in mice and also anticomplementary activity has been studied. The data obtained showed that the n.s.r.i. activity of dextrans generally increased with increase of extent of branching, but no direct correlation between these two factors was found. Data on exodextranase-catalyzed hydrolysis of dextrans suggest that the length of the outer chains may be important for the n.s.r.i. activity of the dextrans. Dextrans characterized by a significant extent of branching were anticomplementary, but no relationship between extent of branching and anticomplementary activity was observed.

摘要

已对六种天然葡聚糖的结构与其对小鼠非特异性抗感染能力(n.s.r.i.)的影响以及抗补体活性之间的关系进行了研究。所获得的数据表明,葡聚糖的n.s.r.i.活性通常随分支程度的增加而提高,但未发现这两个因素之间存在直接关联。关于外切葡聚糖酶催化葡聚糖水解的数据表明,外链的长度可能对葡聚糖的n.s.r.i.活性很重要。具有显著分支程度的葡聚糖具有抗补体作用,但未观察到分支程度与抗补体活性之间的关系。

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Carbohydr Res. 1978 Oct;66:213-23. doi: 10.1016/s0008-6215(00)83254-1.
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