Preobrazhenskaia M E, Danilova N A
Vopr Med Khim. 1977 May-Jun(3):385-91.
An anticomplementary activity of native dextrans of various structure was studied among the nine dextrans studied, eight polymers exhibited the anticomplementary activity of variable magnitude; only one dextran, containing 95% of 1--6 links and 2% of 1--2 links was unactive. The highest activity was exhibited by dextrans with high content of 1--2 links; lower activity was observed in dextrans, containing high amount of 1--3 links. The anticomplementary activity was not found in partially hydrolyzed dextrans, containing 90% and more links of the 1--6 type, with molecular weight of 2-10(6) daltons and lower. Polyaldehydes, obtained from these dextrans by oxidation with iodic acid, acquired the anticomplementary activity, comparable with the activity of native dextrans.
在研究的9种葡聚糖中，对各种结构的天然葡聚糖的抗补体活性进行了研究。在所研究的9种葡聚糖中，8种聚合物表现出不同程度的抗补体活性；只有一种葡聚糖，含有95%的1,6-连接和2%的1,2-连接，没有活性。1,2-连接含量高的葡聚糖表现出最高的活性；1,3-连接含量高的葡聚糖活性较低。在含有90%及以上1,6-型连接、分子量为2×10⁶道尔顿及更低的部分水解葡聚糖中未发现抗补体活性。通过用碘酸氧化这些葡聚糖得到的聚醛具有与天然葡聚糖相当的抗补体活性。
