Eriksson M, Lantz B, Berglund L, Angelin B
Acta Med Scand. 1987;221(3):317-20. doi: 10.1111/j.0954-6820.1987.tb00901.x.
A 40-year-old male with heterozygous familial hypercholesterolaemia was resistant to combined drug treatment with cholestyramine and nicotinic acid in adequate doses. He had angina pectoris and evidence of three vessel disease in the coronary angiogram. Repeated plasma exchange at intervals of 1-3 weeks simultaneously with combined drug treatment decreased the plasma cholesterol levels by nearly 40%. There were also signs of regression of xanthomata and some improvement of his angina pectoris. No progression of atherosclerosis was seen angiographically after two years treatment. Plasma exchange may be a therapeutic alternative in drug-resistant familial hypercholesterolaemia.
一名患有杂合子家族性高胆固醇血症的40岁男性，对使用足够剂量的消胆胺和烟酸进行联合药物治疗耐药。他患有心绞痛，冠状动脉血管造影显示三支血管病变。在联合药物治疗的同时，每隔1至3周重复进行血浆置换，使血浆胆固醇水平降低了近40%。也有黄瘤消退的迹象，其心绞痛也有一定改善。经过两年治疗，血管造影显示动脉粥样硬化没有进展。对于耐药性家族性高胆固醇血症，血浆置换可能是一种治疗选择。
