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Comprehensive analysis of lower mitochondrial complex I expression is associated with cell metastasis of clear cell renal cell carcinoma.低线粒体复合物I表达的综合分析与透明细胞肾细胞癌的细胞转移相关。
Transl Cancer Res. 2022 Jun;11(6):1488-1502. doi: 10.21037/tcr-22-242.
2
Base editing in mitochondrial DNA.线粒体DNA中的碱基编辑
Nat Methods. 2022 Jun;19(6):640. doi: 10.1038/s41592-022-01532-0.
3
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis.血清线粒体tsRNA作为肝癌诊断的新型生物标志物。
Front Med. 2022 Apr;16(2):216-226. doi: 10.1007/s11684-022-0920-7. Epub 2022 Apr 13.
4
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective.线粒体与核之间的通讯在衰老中的作用：一种表观遗传学视角。
Trends Biochem Sci. 2022 Aug;47(8):645-659. doi: 10.1016/j.tibs.2022.03.008. Epub 2022 Apr 6.
5
Mitochondria-actin cytoskeleton crosstalk in cell migration.线粒体-肌动蛋白细胞骨架在细胞迁移中的相互作用。
J Cell Physiol. 2022 May;237(5):2387-2403. doi: 10.1002/jcp.30729. Epub 2022 Mar 27.
6
Specialized Intercellular Communications via Tunnelling Nanotubes in Acute and Chronic Leukemia.急性和慢性白血病中通过隧道纳米管进行的特殊细胞间通讯
Cancers (Basel). 2022 Jan 28;14(3):659. doi: 10.3390/cancers14030659.
7
Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma.鉴定与神经母细胞瘤风险相关的线粒体 DNA 变异。
J Natl Cancer Inst. 2022 Jun 13;114(6):910-913. doi: 10.1093/jnci/djac012.
8
Mitochondrial fragmentation is crucial for c-Myc-driven hepatoblastoma-like liver tumors.线粒体碎片化对于 c-Myc 驱动的肝母细胞瘤样肝肿瘤至关重要。
Mol Ther. 2022 Apr 6;30(4):1645-1660. doi: 10.1016/j.ymthe.2022.01.032. Epub 2022 Jan 24.
9
Mitochondrial DNA copy number and disease.线粒体DNA拷贝数与疾病
Nat Rev Genet. 2022 Mar;23(3):136. doi: 10.1038/s41576-022-00451-2.
10
The portrait of liver cancer is shaped by mitochondrial genetics.肝癌的特征受线粒体遗传因素的影响。
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线粒体遗传学在癌症转移中的作用。

Roles of mitochondrial genetics in cancer metastasis.

作者信息

Welch Danny R, Foster Christian, Rigoutsos Isidore

机构信息

Department of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; Department of Internal Medicine (Hematology/Oncology), The Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; Department of Molecular and Integrative Physiology, The Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; Department of Pathology, The Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA; The University of Kansas Comprehensive Cancer Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

Department of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

出版信息

Trends Cancer. 2022 Dec;8(12):1002-1018. doi: 10.1016/j.trecan.2022.07.004. Epub 2022 Jul 29.

DOI:10.1016/j.trecan.2022.07.004
PMID:35915015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9884503/
Abstract

The contributions of mitochondria to cancer have been recognized for decades. However, the focus on the metabolic role of mitochondria and the diminutive size of the mitochondrial genome compared to the nuclear genome have hindered discovery of the roles of mitochondrial genetics in cancer. This review summarizes recent data demonstrating the contributions of mitochondrial DNA (mtDNA) copy-number variants (CNVs), somatic mutations, and germline polymorphisms to cancer initiation, progression, and metastasis. The goal is to summarize accumulating data to establish a framework for exploring the contributions of mtDNA to neoplasia and metastasis.

摘要

几十年来，线粒体对癌症的作用已得到认可。然而，由于对线粒体代谢作用的关注以及与核基因组相比线粒体基因组规模较小，阻碍了对线粒体遗传学在癌症中作用的发现。本综述总结了近期数据，这些数据表明线粒体DNA（mtDNA）拷贝数变异（CNV）、体细胞突变和种系多态性对癌症的发生、发展和转移的作用。目的是总结不断积累的数据，以建立一个框架来探索mtDNA对肿瘤形成和转移的作用。