Department of Biology, Indian Institute of Science Education and Research, Pune, India.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Cell Physiol. 2022 May;237(5):2387-2403. doi: 10.1002/jcp.30729. Epub 2022 Mar 27.
Mitochondria perform diverse functions in the cell and their roles during processes such as cell survival, differentiation, and migration are increasingly being appreciated. Mitochondrial and actin cytoskeletal networks not only interact with each other, but this multifaceted interaction shapes their functional dynamics. The interrelation between mitochondria and the actin cytoskeleton extends far beyond the requirement of mitochondrial ATP generation to power actin dynamics, and impinges upon several major aspects of cellular physiology. Being situated at the hub of cell signaling pathways, mitochondrial function can alter the activity of actin regulatory proteins and therefore modulate the processes downstream of actin dynamics such as cellular migration. As we will discuss, this regulation is highly nuanced and operates at multiple levels allowing mitochondria to occupy a strategic position in the regulation of migration, as well as pathological events that rely on aberrant cell motility such as cancer metastasis. In this review, we summarize the crosstalk that exists between mitochondria and actin regulatory proteins, and further emphasize on how this interaction holds importance in cell migration in normal as well as dysregulated scenarios as in cancer.
线粒体在细胞中执行多种功能，其在细胞存活、分化和迁移等过程中的作用正日益受到重视。线粒体和肌动蛋白细胞骨架网络不仅相互作用，而且这种多方面的相互作用塑造了它们的功能动态。线粒体和肌动蛋白细胞骨架之间的关系远不止于需要线粒体 ATP 生成来为肌动蛋白动力学提供动力，而且还影响到细胞生理学的几个主要方面。线粒体位于细胞信号通路的中心，其功能可以改变肌动蛋白调节蛋白的活性，从而调节肌动蛋白动力学下游的过程，如细胞迁移。正如我们将讨论的那样，这种调节非常精细，并在多个层次上进行，使线粒体在迁移的调节以及依赖异常细胞运动的病理事件（如癌症转移）中占据战略地位。在这篇综述中，我们总结了线粒体和肌动蛋白调节蛋白之间存在的串扰，并进一步强调了这种相互作用在正常和失调情况下（如癌症）细胞迁移中的重要性。
