Sidransky H
Adv Exp Med Biol. 1986;206:187-207. doi: 10.1007/978-1-4613-1835-4_16.
This paper reviews some of the earlier experimental studies concerning the role that tryptophan plays in enhancing tumorigenesis induced by selected chemical carcinogens. For many years, tryptophan has been implicated in carcinogenesis of the bladder. The evidence regarding tryptophan's effect on hepatic tumorigenesis is conflicting; an enhancing effect has been reported by some investigators, but a reduction in tumorigenesis has been reported by other workers. Some of the unique effects that tryptophan exerts upon the liver are reviewed. Also, experimental studies from our laboratory are reported in which we observed a potentiating effect of increased dietary tryptophan on the induction of gamma-glutamyltranspeptidase-positive foci in liver when rats were fed a choline-supplemented diet but no potentiation was found when rats were fed a choline-deficient diet for 10 weeks. The results suggest that increased dietary tryptophan has a promoting effect on liver carcinogenesis as measured by the induction of gamma-glutamyltranspeptidase-positive foci in the livers of rats exposed to diethylnitrosamine. The possible significance of these findings is reviewed.
本文回顾了一些早期的实验研究，这些研究涉及色氨酸在增强某些化学致癌物诱导的肿瘤发生过程中所起的作用。多年来，色氨酸一直被认为与膀胱癌的发生有关。关于色氨酸对肝脏肿瘤发生影响的证据相互矛盾；一些研究人员报告了增强作用，但其他研究人员则报告了肿瘤发生的减少。本文回顾了色氨酸对肝脏产生的一些独特作用。此外，还报告了我们实验室的实验研究，我们观察到，当给大鼠喂食补充胆碱的饮食时，增加饮食中的色氨酸会增强肝脏中γ-谷氨酰转肽酶阳性灶的诱导，但当给大鼠喂食10周胆碱缺乏饮食时，则未发现增强作用。结果表明，以暴露于二乙基亚硝胺的大鼠肝脏中γ-谷氨酰转肽酶阳性灶的诱导为衡量标准，增加饮食中的色氨酸对肝癌发生有促进作用。本文还对这些发现的可能意义进行了回顾。
