Rondinelli R C, Koenig J Q, Marshall S G
Am Ind Hyg Assoc J. 1987 Apr;48(4):299-303. doi: 10.1080/15298668791384797.
To determine whether normal nonsmoking individuals aged 55 years or greater have heightened bronchial reactivity to inhaled SO2, ten male subjects, 55 to 73 years of age, were exposed for 20 min at rest and 10 min during moderate exercise on a treadmill to the following: NaCl droplet aerosol, or 1.0 ppm of SO2 and NaCl droplet aerosol. Seven of the subjects also were exposed to 0.5 ppm SO2 and NaCl droplet aerosol. Significant decrease in forced expiratory volume in one sec (FEV1) were seen 2-3 min post-exercise following all three test modes. The reduction in FEV1 seen after NaCl aerosol + 1.0 ppm SO2 was significantly greater than that seen after NaCl aerosol alone. The results show that men aged 55 years or older are somewhat more sensitive to NaCl aerosol + 1.0 ppm SO2 than similarly exposed normal adolescents, but not nearly as sensitive as asthmatic subjects. This study also demonstrates that investigations of air pollutants and exercise can be undertaken in subjects of this age.
为了确定55岁及以上的正常不吸烟个体对吸入的二氧化硫是否具有更高的支气管反应性，选取了10名年龄在55至73岁之间的男性受试者，让他们在静息状态下暴露20分钟，并在跑步机上进行适度运动期间暴露10分钟，暴露于以下物质：氯化钠液滴气雾剂，或1.0 ppm的二氧化硫和氯化钠液滴气雾剂。其中7名受试者还暴露于0.5 ppm的二氧化硫和氯化钠液滴气雾剂。在所有三种测试模式后的运动后2至3分钟，观察到一秒用力呼气量（FEV1）显著下降。氯化钠气雾剂 + 1.0 ppm二氧化硫后观察到的FEV1降低显著大于单独使用氯化钠气雾剂后的降低。结果表明，55岁及以上的男性对氯化钠气雾剂 + 1.0 ppm二氧化硫的敏感性略高于同样暴露的正常青少年，但远不如哮喘患者敏感。这项研究还表明，可以在这个年龄段的受试者中进行空气污染物与运动的研究。
