Kim H, Kim K, Kim Y H
Department of Laboratory Medicine, Pusan National University Hospital, Busan, Republic of Korea.
Eur Rev Med Pharmacol Sci. 2022 Jul;26(14):4997-5007. doi: 10.26355/eurrev_202207_29286.
Considering the impact of mental illness and cancer on the society, the relationship between the two diseases should be assessed. This study aimed at determining the association between mental illness and cancer.
The Embase and Medline databases were searched on October 21, 2020. Cohort, case-control, and cross-sectional studies were eligible for study inclusion. The Newcastle-Ottawa scale was used to qualitatively assess the risk of bias. Funnel plots were drawn to evaluate the risks of bias across the included studies.
We included 58 studies from 16 countries, incorporating approximately 30 national databases and 25 million individuals. Patients with psychiatric disorders did not show an increased risk of developing cancer. However, patients with cancer had a significantly increased risk of developing mental illness. The survival rates of patients with mental illness according to cancer occurrence and patients with cancer according to mental illness occurrence were significantly decreased.
Clinicians should conduct early screening to ensure that appropriate interventions for mental illness are administered in patients with cancer. Due to the high incidence of death in patients with mental illnesses due to unnatural causes, such as suicide, homicide, and accidents, clinicians should be aware of the importance of the treatment and management of these patients.
鉴于精神疾病和癌症对社会的影响，应评估这两种疾病之间的关系。本研究旨在确定精神疾病与癌症之间的关联。
于2020年10月21日检索了Embase和Medline数据库。队列研究、病例对照研究和横断面研究均符合纳入标准。采用纽卡斯尔-渥太华量表对偏倚风险进行定性评估。绘制漏斗图以评估纳入研究中的偏倚风险。
我们纳入了来自16个国家的58项研究，涉及约30个国家数据库和2500万人。患有精神疾病的患者患癌症的风险并未增加。然而，患有癌症的患者患精神疾病的风险显著增加。根据是否患癌症划分的精神疾病患者的生存率以及根据是否患精神疾病划分的癌症患者的生存率均显著降低。
临床医生应进行早期筛查，以确保对癌症患者实施适当的精神疾病干预措施。由于精神疾病患者因自杀、凶杀和事故等非自然原因导致的高死亡率，临床医生应意识到对这些患者进行治疗和管理的重要性。
