Department of Respiratory Medicine, Department of Cardiology, Zaozhuang Municipal Hospital, Zaozhuang, China.
Eur Rev Med Pharmacol Sci. 2022 Jul;26(14):5081-5091. doi: 10.26355/eurrev_202207_29294.
It has been shown that asthma is significantly associated with the risk of cardiovascular disease (CVD). Under this background, this study aimed to systematically classify and summarize the epidemiological evidence of asthma and the risk of 4 specific cardiovascular diseases (CVDs) and cardiovascular mortality (CVM).
PubMed and Embase databases were searched from inception to December 1st, 2021 in order to identify relevant studies. The random-model was used to assess the pooled results. All pooled results were expressed as risk ratios (RRs) and corresponding 95% confidence intervals (CIs).
Finally, a total of 18 studies were included in the present meta-analysis. Compared with non-asthmatic group, patients with asthma had significantly increased risks of subsequent cardiovascular heart disease (CHD, RR 1.33; 1.19-1.50, I2=80.3%; p<0.001), and CVM (RR 1.35; 1.15-1.59, I2=0%; p<0.001). Similarly, the risks of heart failure (HF, RR 2.10; 1.98-2.22, I2=17.4%; p<0.001) and myocardial infraction (MI, RR 1.39; 1.16-1.66, I2=59.3%; p<0.001) were higher in the asthmatic population. However, the higher risk of atrial fibrillation (RR 1.70; 1.45-2.00, I2=0%; p<0.001) was observed only in the active asthmatic population.
In general, asthma is associated with subsequent increased risks of CHD, MI, AF, HF, and CVM. In addition, among patients with asthma, females have a higher risk of CHD than males, while active asthmatic patients have a higher risk of CVM than non-active asthmatic patients.
已经表明哮喘与心血管疾病（CVD）的风险显著相关。在此背景下，本研究旨在系统地分类和总结哮喘与 4 种特定心血管疾病（CVD）和心血管死亡率（CVM）风险的流行病学证据。
为了识别相关研究，从建立到 2021 年 12 月 1 日，在 PubMed 和 Embase 数据库中进行了搜索。使用随机模型评估汇总结果。所有汇总结果均表示为风险比（RR）和相应的 95%置信区间（CI）。
最终，本荟萃分析共纳入 18 项研究。与非哮喘组相比，哮喘患者发生后续心血管心脏病（CHD，RR 1.33；1.19-1.50，I2=80.3%；p<0.001）和 CVM（RR 1.35；1.15-1.59，I2=0%；p<0.001）的风险显著增加。同样，心力衰竭（HF，RR 2.10；1.98-2.22，I2=17.4%；p<0.001）和心肌梗死（MI，RR 1.39；1.16-1.66，I2=59.3%；p<0.001）的风险在哮喘人群中也更高。然而，仅在活动性哮喘人群中观察到心房颤动（RR 1.70；1.45-2.00，I2=0%；p<0.001）的风险更高。
一般来说，哮喘与随后发生的 CHD、MI、AF、HF 和 CVM 风险增加相关。此外，在哮喘患者中，女性患 CHD 的风险高于男性，而活动性哮喘患者的 CVM 风险高于非活动性哮喘患者。
