Schölmerich J, Krauss E, Wietholtz H, Köttgen E, Löhle E, Gerok W
Am J Clin Nutr. 1987 Jun;45(6):1487-91. doi: 10.1093/ajcn/45.6.1487.
Supplementation may benefit patients with liver cirrhosis. Zinc uptake from zinc-histidine complex 1:2 was assessed in eight patients with liver cirrhosis. Influence of the time of application was also studied. Compared with healthy controls, patients showed a 40% lower uptake of zinc after 20 mg zinc from zinc histidine. Bioavailability was identical when zinc was taken 6 h or 1 h before a meal but an order of magnitude greater than with or 1 h after a meal. No significant increase of serum zinc was found when zinc was given with a meal or 1 h after. Lower doses of zinc-histidine complexes than of zinc sulfate may be used to supplement patients with liver cirrhosis. Time of application is of great importance if this substitution is to be successful.
补充剂可能对肝硬化患者有益。对8例肝硬化患者评估了从1:2的锌-组氨酸复合物中摄取锌的情况。还研究了给药时间的影响。与健康对照组相比，患者从锌组氨酸中摄取20毫克锌后，锌的摄取量降低了40%。饭前6小时或1小时服用锌时生物利用度相同，但比饭后服用或饭后1小时服用时高一个数量级。饭后服用锌或饭后1小时服用锌时，血清锌没有显著增加。与硫酸锌相比，较低剂量的锌-组氨酸复合物可用于补充肝硬化患者。如果要成功进行这种替代，给药时间非常重要。
