Lui Jason L, Hakam Nizar, Shaw Nathan M, Cuschieri Joseph, Abbasi Behzad, Breyer Benjamin N
Department of Urology, University of California San Francisco, San Francisco, California.
Department of Surgery, University of California San Francisco, San Francisco, California.
J Urol. 2022 Nov;208(5):1090-1097. doi: 10.1097/JU.0000000000002831. Epub 2022 Aug 2.
Alcohol intoxication is a known risk factor for motor vehicle collisions. We hypothesize ethanol intoxication increases the risk of bladder injury and surgical repair, especially at higher blood alcohol content levels.
We identified all patients involved in motor vehicle collisions from the National Trauma Data Bank from 2017-2019. Patients were categorized into an intoxication and intoxication negative group. Variables collected included age, sex, blood alcohol content level, driver status, seat belt restraint use, nonalcoholic intoxication, pelvic fracture, and Injury Severity Scale. Primary outcome measures of bladder injury and bladder surgical repair were assessed and interaction with pelvic fracture and restraint use were measured.
We identified 594,484 patients and 97,831 (16.5%) had a positive alcohol screen. Patients in the intoxication group were more likely to be intoxicated with other substances (32.8% vs 14.6%, .001), have a bladder injury (1% vs 0.4%, .001) and receive bladder surgical repair (0.7% vs 0.15%, .001). Injury Severity Scale and pelvic fracture were statistically significant predictors of bladder injury. In adjusted analysis, higher blood alcohol content was associated with both outcomes. Above the legal limit, alcohol intoxication was more predictive of bladder surgical repair than pelvic fracture. The association of alcohol intoxication with both outcomes did not differ by pelvic fracture, but strengthened with seat belt use at higher intoxication levels.
Alcohol intoxication is independently associated with increased risk of bladder injury and subsequent bladder surgical repair following motor vehicle collisions. Trauma providers should have a high index of suspicion for bladder injuries in alcohol intoxicated patients, particularly those using seat belt restraints.
酒精中毒是机动车碰撞事故的一个已知风险因素。我们假设乙醇中毒会增加膀胱损伤和手术修复的风险,尤其是在血液酒精含量较高时。
我们从国家创伤数据库中识别出2017年至2019年期间所有参与机动车碰撞事故的患者。患者被分为中毒组和非中毒组。收集的变量包括年龄、性别、血液酒精含量水平、驾驶员状态、安全带使用情况、非酒精性中毒、骨盆骨折和损伤严重程度评分。评估膀胱损伤和膀胱手术修复的主要结局指标,并测量与骨盆骨折和安全带使用的相互作用。
我们识别出594,484名患者,其中97,831名(16.5%)酒精筛查呈阳性。中毒组患者更有可能同时使用其他物质中毒(32.8%对14.6%,P<0.001),发生膀胱损伤(1%对0.4%,P<0.001)并接受膀胱手术修复(0.7%对0.15%,P<0.001)。损伤严重程度评分和骨盆骨折是膀胱损伤的统计学显著预测因素。在多因素分析中,较高的血液酒精含量与这两个结局均相关。超过法定限度后,酒精中毒比骨盆骨折更能预测膀胱手术修复。酒精中毒与这两个结局的关联在骨盆骨折方面无差异,但在较高中毒水平下,安全带使用会增强这种关联。
酒精中毒与机动车碰撞后膀胱损伤及随后膀胱手术修复风险增加独立相关。创伤救治人员应对酒精中毒患者,尤其是那些使用安全带的患者的膀胱损伤保持高度怀疑。