Yang Xiaojie, Shen Zhimin, Tian Mengyue, Lin Yukang, Li Liming, Chai Tianci, Zhang Peipei, Kang Mingqiang, Lin Jiangbo
Department of Thoracic Surgery, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou 350001, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, China.
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Transl Oncol. 2022 Oct;24:101487. doi: 10.1016/j.tranon.2022.101487. Epub 2022 Jul 30.
Increasing evidence has indicated that long non-coding RNAs (LncRNAs) play multiple functions in the development of cancer and function as indicators of diagnosis and prognosis. This aim of this study was to investigate the roles LncRNA C9orF139 had in the progression of esophageal squamous carcinoma (ESCC). We found C9orf139 was highly expressed in ESCC and knock down the expression of C9orf139 significantly suppressed cell proliferation, promoted apoptosis, and inhibited migration and invasion. C9orf139 was able to negatively regulate miR-661 expression. At the same time, HDAC11 expression was negatively regulated by miR-661. The C9orf139/miR-661/HDAC11 axis was further involved in regulating the expression of the NF-κB signaling pathway. The association between the C9orf139 knockdown and the reduced tumor growth and size was observed during in vivo study. C9orf139 is highly expressed in ESCC, and is thus qualified to be used as a potential diagnostic and prognostic marker for ESCC. Its promotion of ESCC progression is achieved by mediating the miR-661/HDAC11 axis.
越来越多的证据表明，长链非编码RNA（LncRNAs）在癌症发展中发挥多种功能，并作为诊断和预后指标。本研究的目的是探讨LncRNA C9orF139在食管鳞状细胞癌（ESCC）进展中的作用。我们发现C9orf139在ESCC中高表达，敲低C9orf139的表达可显著抑制细胞增殖、促进细胞凋亡，并抑制迁移和侵袭。C9orf139能够负向调节miR-661的表达。同时，miR-661负向调节HDAC11的表达。C9orf139/miR-661/HDAC11轴进一步参与调节NF-κB信号通路的表达。在体内研究中观察到敲低C9orf139与肿瘤生长和大小减小之间的关联。C9orf139在ESCC中高表达，因此有资格作为ESCC的潜在诊断和预后标志物。它通过介导miR-661/HDAC11轴促进ESCC进展。
