Franks A L, Lee N C, Kendrick J S, Rubin G L, Layde P M
Am J Epidemiol. 1987 Jul;126(1):112-7. doi: 10.1093/oxfordjournals.aje.a114642.
Cigarette smoking may affect each of the currently proposed mechanisms of ovarian carcinogenesis. Whether cigarette smoking has any effect on the development of ovarian cancer has not been adequately evaluated. To study this issue, the authors examined data from the Cancer and Steroid Hormone Study, a multicenter, case-control study of gynecologic cancers conducted between December 1, 1980, and December 31, 1982, in eight geographic areas of the United States. This analysis utilized data on 494 women with newly diagnosed epithelial ovarian cancer and 4,238 population-based control women 20-54 years of age. There was no association of epithelial ovarian cancer with dose of cigarette smoking, age smoking started, time since smoking started, or time since smoking last occurred. Simultaneous adjustment for age, parity, history of oral contraceptive use, and other potentially confounding factors did not alter these results.
吸烟可能会影响目前提出的卵巢癌发生的每一种机制。吸烟对卵巢癌的发展是否有任何影响尚未得到充分评估。为了研究这个问题，作者检查了癌症与类固醇激素研究的数据，这是一项多中心、病例对照研究，于1980年12月1日至1982年12月31日在美国八个地理区域进行，涉及妇科癌症。该分析利用了494名新诊断为上皮性卵巢癌的女性和4238名年龄在20至54岁之间的基于人群的对照女性的数据。上皮性卵巢癌与吸烟剂量、开始吸烟的年龄、开始吸烟后的时间或上次吸烟后的时间均无关联。同时对年龄、生育次数、口服避孕药使用史和其他潜在混杂因素进行调整并没有改变这些结果。
