Colditz G A
Brigham and Women's Hospital, Boston, Massachusetts.
Ann Intern Med. 1994 May 15;120(10):821-6. doi: 10.7326/0003-4819-120-10-199405150-00002.
To examine prospectively the risk for mortality among women who had ever used oral contraceptives compared with those who had never used oral contraceptives.
Prospective cohort study.
Nurses' Health Study.
166,755 women aged 30 to 55 years in 1976, followed through 1988 (1.3 million person-years of follow-up).
On the basis of 2879 deaths, we found no overall difference in mortality among women who had ever used oral contraceptives compared with women who had never used oral contraceptives; the relative risk for ever-users, adjusted for age, body mass index, and cigarette smoking was 0.93 (95% CI, 0.85 to 1.01). We observed no trend in risk for total mortality with increasing duration of past use of oral contraceptives. After adjusting for age, body mass index, and cigarette smoking, women who had used oral contraceptives for 10 or more years had a relative risk of 1.06 (CI, 0.83 to 1.35).
Use of oral contraceptives is safe; no evidence from this study indicates that long durations of oral contraceptive use adversely affect long-term risk for mortality.
前瞻性地研究曾经使用口服避孕药的女性与从未使用口服避孕药的女性相比的死亡风险。
前瞻性队列研究。
护士健康研究。
1976年年龄在30至55岁之间的166,755名女性，随访至1988年（随访人年数达130万）。
基于2879例死亡病例，我们发现曾经使用口服避孕药的女性与从未使用口服避孕药的女性在死亡率上没有总体差异；在对年龄、体重指数和吸烟情况进行调整后，曾经使用者的相对风险为0.93（95%可信区间，0.85至1.01）。我们没有观察到随着过去使用口服避孕药时间的增加，总死亡率风险有任何趋势。在对年龄、体重指数和吸烟情况进行调整后，曾经使用口服避孕药10年或更长时间的女性相对风险为1.06（可信区间，0.83至1.35）。
使用口服避孕药是安全的；本研究没有证据表明长期使用口服避孕药会对长期死亡风险产生不利影响。
