Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China; Tianjin Interdisciplinary Innovation Centre for Health and Meteorology, Tianjin, China.
Environ Pollut. 2022 Oct 1;310:119827. doi: 10.1016/j.envpol.2022.119827. Epub 2022 Jul 30.
Under the background of global industrialization, PM has become the fourth-leading risk factor for ischemic stroke worldwide, according to the 2019 GBD estimates. This highlights the hazards of PM for ischemic stroke, but unfortunately, PM has not received the attention that matches its harmfulness. This article is the first to systematically describe the molecular biological mechanism of PM-induced ischemic stroke, and also propose potential therapeutic and intervention strategies. We highlight the effect of PM on traditional cerebrovascular risk factors (hypertension, hyperglycemia, dyslipidemia, atrial fibrillation), which were easily overlooked in previous studies. Additionally, the effects of PM on platelet parameters, megakaryocytes activation, platelet methylation, and PM-induced oxidative stress, local RAS activation, and miRNA alterations in endothelial cells have also been described. Finally, PM-induced ischemic brain pathological injury and microglia-dominated neuroinflammation are discussed. Our ultimate goal is to raise the public awareness of the harm of PM to ischemic stroke, and to provide a certain level of health guidance for stroke-susceptible populations, as well as point out some interesting ideas and directions for future clinical and basic research.
在全球工业化的背景下，根据 2019 年 GBD 的估计，PM 已成为全球缺血性中风的第四大主要风险因素。这突显了 PM 对缺血性中风的危害，但不幸的是，PM 尚未受到与其危害性相匹配的关注。本文首次系统描述了 PM 诱导缺血性中风的分子生物学机制，并提出了潜在的治疗和干预策略。我们强调了 PM 对传统脑血管危险因素（高血压、高血糖、血脂异常、心房颤动）的影响，这在以前的研究中很容易被忽视。此外，还描述了 PM 对血小板参数、巨核细胞激活、血小板甲基化以及 PM 诱导的氧化应激、局部 RAS 激活和内皮细胞中 miRNA 改变的影响。最后，讨论了 PM 诱导的缺血性脑病理损伤和小胶质细胞主导的神经炎症。我们的最终目标是提高公众对 PM 对缺血性中风危害的认识，并为易患中风的人群提供一定水平的健康指导，同时为未来的临床和基础研究指出一些有趣的思路和方向。
