Mufson M A, Krause H E, Schiffman G, Hughey D F
Am J Med Sci. 1987 May;293(5):279-84. doi: 10.1097/00000441-198705000-00001.
The authors investigated the persistence of anticapsular pneumococcal antibodies in 21 subjects one decade after administration of a single dose of a polyvalent pneumococcal polysaccharide vaccine. Fourteen vaccinees received a hexavalent vaccine composed of the polysaccharides of capsular types 1, 3, 4, 7F, 8, and 12F; four vaccinees received an octavalent vaccine consisting of these six polysaccharides and also those of capsular types 14 and 19F; and three vaccinees received a nonavalent vaccine that also included type 5 capsular polysaccharide. Antibody was measured by radioimmunoassay. The authors detected persistently elevated anticapsular antibody levels among more than one half of vaccinees who developed a significant rise in antibody 1 month following immunization one decade after administration of pneumococcal polysaccharide vaccine when these levels were compared to prevaccine levels for pneumococcal capsular types 4, 7F, and 8. This finding was not the case with pneumococcal types 1, 3, 12F, 14, and 19F; less than two fifths of vaccinees maintained increased levels of anticapsular antibody to these types one decade after administration of pneumococcal vaccine. Geometric mean anticapsular antibody levels for types 7F and 8 only were significantly higher one decade after vaccine administration compared with the levels before immunization (t-test, p less than 0.01).
作者对21名受试者在接种单剂量多价肺炎球菌多糖疫苗十年后抗肺炎球菌荚膜抗体的持久性进行了研究。14名接种者接种了由1、3、4、7F、8和12F型荚膜多糖组成的六价疫苗；4名接种者接种了八价疫苗，该疫苗由这六种多糖以及14和19F型荚膜多糖组成；3名接种者接种了九价疫苗，其中还包括5型荚膜多糖。通过放射免疫测定法检测抗体。当将这些水平与肺炎球菌多糖疫苗接种十年后免疫1个月后抗体显著升高的接种者中超过一半的人相比，作者检测到肺炎球菌4、7F和8型的抗荚膜抗体水平持续升高，与接种前水平相比。对于1、3、12F、14和19F型肺炎球菌则并非如此；在接种肺炎球菌疫苗十年后，不到五分之二的接种者对这些类型的抗荚膜抗体水平保持升高。仅7F和8型的几何平均抗荚膜抗体水平在疫苗接种十年后与免疫前水平相比显著更高（t检验，p小于0.01）。
