Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cytokine Growth Factor Rev. 2022 Oct;67:35-48. doi: 10.1016/j.cytogfr.2022.07.006. Epub 2022 Jul 22.
Since the "seed and soil" hypothesis was proposed, the biological functions of the tumor microenvironment (TME), especially its stromal components, have received increasing attention. Cancer-associated fibroblasts (CAFs) are the major components of the stromal region, providing material support for tumor cell proliferation, migration, and invasion. Furthermore, CAFs are important mediators of suppressing immune responses by attracting the accumulation of immunosuppressive cells through cytokine/chemokine secretion. In this review, we summarized the major cytokines, chemokines and metabolites, including transforming growth factor-β (TGF-β), interleukin-6 (IL-6), C-X-C chemokine ligand (CXCL)12, C-C chemokine ligand (CCL) 2, prostaglandin E2 (PGE2), and other factors, by which CAFs suppress the immune systems in a variety of cancers. More importantly, we highlight potential therapeutic strategies to alleviate the immunosuppression produced by CAFs, thereby inhibiting tumor progression.
自“种子与土壤”假说提出以来，肿瘤微环境（TME）的生物学功能，尤其是其基质成分，受到了越来越多的关注。肿瘤相关成纤维细胞（CAFs）是基质区域的主要组成部分，为肿瘤细胞的增殖、迁移和侵袭提供物质支持。此外，CAFs 通过细胞因子/趋化因子分泌吸引免疫抑制细胞的积累，是抑制免疫反应的重要介质。在这篇综述中，我们总结了 CAFs 通过多种癌症中 TGF-β、IL-6、CXCL12、CCL2、PGE2 等主要细胞因子、趋化因子和代谢物抑制免疫系统的作用。更重要的是，我们强调了缓解 CAFs 产生的免疫抑制的潜在治疗策略，从而抑制肿瘤的进展。
