Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nutr Metab Cardiovasc Dis. 2022 Sep;32(9):2177-2186. doi: 10.1016/j.numecd.2022.06.005. Epub 2022 Jun 13.
The joint effect of famine exposure and adulthood obesity on risk of dyslipidemia remains unclear. Thus, we aim to explore the joint effect of famine exposure and adulthood obesity on the risk of dyslipidemia, and the potential effect of adult general or abdominal obesity on the association between famine exposure and dyslipidemia.
We conducted a community-based cohort study in 8880 subjects aged 40 years or older. Participants were divided into nonexposed, fetal-exposed, childhood-exposed, adolescent-exposed according to birth date. General obesity and abdominal obesity were defined according to body mass index (BMI: overweight≥24.0 kg/m, obesity≥28.0 kg/m) and waist-to-hip ratio (WHR, men/women: moderate≥0.90/0.85, high≥0.95/0.90). Dyslipidemia was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Compared with nonexposed participants, fetal-exposed individuals had significantly increased risk of dyslipidemia (OR:1.24, 95%CI: 1.03-1.50) in the whole study. Significant increased risk of dyslipidemia related to famine exposure was observed in women [ORs (95%CIs) were 1.36 (1.05-1.76) and 1.70 (1.22-2.37) for the fetal and childhood-exposed group, respectively] but not in men. Moreover, both general and central obesity had significant multiplicative interactions with famine exposure for the risk of dyslipidemia (P for interaction = 0.0001 and < 0.0001, respectively). Significant additive interaction was found between famine exposure and WHR on risk of dyslipidemia in women, with the relative excess risk due to interaction (RERI) and 95% CI of 0.43 (0.10-0.76).
Coexistence of early-life undernutrition and adulthood obesity was associated with a higher risk of dyslipidemia in later life.
饥荒暴露和成年肥胖对血脂异常风险的联合影响尚不清楚。因此，我们旨在探讨饥荒暴露和成年肥胖对血脂异常风险的联合影响，以及成年普通肥胖或腹部肥胖对饥荒暴露与血脂异常之间关系的潜在影响。
我们对 8880 名年龄在 40 岁或以上的社区居民进行了一项基于社区的队列研究。根据出生日期，参与者被分为未暴露组、胎儿暴露组、儿童暴露组和青少年暴露组。普通肥胖和腹部肥胖根据体重指数（BMI：超重≥24.0 kg/m，肥胖≥28.0 kg/m）和腰臀比（WHR，男性/女性：中度≥0.90/0.85，高度≥0.95/0.90）定义。血脂异常采用国家胆固醇教育计划成人治疗专家组 III 标准定义。与未暴露组参与者相比，胎儿暴露组血脂异常的风险显著增加（OR：1.24，95%CI：1.03-1.50）。在女性中观察到与饥荒暴露相关的血脂异常风险显著增加[胎儿和儿童暴露组的 ORs（95%CI）分别为 1.36（1.05-1.76）和 1.70（1.22-2.37）]，但在男性中则不然。此外，普通肥胖和中心性肥胖与饥荒暴露对血脂异常的风险均具有显著的乘法交互作用（交互作用的 P 值均<0.0001）。在女性中，还发现了饥荒暴露与 WHR 之间在血脂异常风险方面存在显著的相加交互作用，交互作用的相对超额风险（RERI）及其 95%CI 为 0.43（0.10-0.76）。
早期生活营养不良和成年肥胖共存与晚年血脂异常风险增加有关。
