Hida T, Sheta S M, Proia A D, McCuen B W
Am J Ophthalmol. 1987 Jun 15;103(6):782-9. doi: 10.1016/s0002-9394(14)74394-6.
We evaluated the use of transvitreal cyanoacrylate retinopexy in the treatment of experimental rhegmatogenous retinal detachment during vitreous surgery in the cynomolgus monkey. The chorioretinal adhesions produced with cyanoacrylate tissue adhesive as compared with those produced by transscleral retinal cryopexy were more rapid in onset as well as stronger. To test the efficacy of cyanoacrylate retinopexy further, a 360-degree peripheral retinectomy was created in five eyes with circumferential cyanoacrylate application to the posterior retinal edge. The cyanoacrylate retinopexy did not prevent the development of proliferative vitreoretinopathy with traction retinal detachment, but in three of the eyes the tissue adhesive continued to maintain retinal apposition to the retinal pigment epithelium at the retinotomy edge. Histologic examination of the retinas disclosed a foreign body reaction adjacent to the cyanoacrylate sites, but there was no evidence of any distant effects caused by the tissue adhesive.
我们评估了在猕猴玻璃体手术期间，经玻璃体腔应用氰基丙烯酸酯进行视网膜固定术在治疗实验性孔源性视网膜脱离中的应用。与经巩膜视网膜冷冻疗法相比，使用氰基丙烯酸酯组织黏合剂产生的脉络膜视网膜粘连起效更快且更强。为了进一步测试氰基丙烯酸酯视网膜固定术的疗效，在五只眼睛中进行了360度周边视网膜切除术，并在视网膜后缘环形应用氰基丙烯酸酯。氰基丙烯酸酯视网膜固定术未能阻止增生性玻璃体视网膜病变伴牵引性视网膜脱离的发展，但在三只眼中，组织黏合剂在视网膜切开边缘处持续保持视网膜与视网膜色素上皮的贴附。对视网膜的组织学检查显示，氰基丙烯酸酯部位附近存在异物反应，但没有证据表明该组织黏合剂会产生任何远处影响。
