Institute of Medical Science and SUM Hospital, Kalinga Nagar, Ghatikia, Bhubaneswar, Odisha, India.
Chakrabarti Eye Care Centre, Trivandrum, Kerala, India.
Indian J Ophthalmol. 2022 Aug;70(8):2889-2894. doi: 10.4103/ijo.IJO_3007_21.
To assess the role of lens parameters in the detection and progression of primary angle-closure disease (PACD) by combining A-scan and A-scan optical coherence tomography (AS-OCT) parameters.
A cross-sectional study was conducted in a tertiary health-care center in eastern India. A total of 91 study subjects including cases and controls were included in the study. The parameters studied were lens thickness (LT), lens axial factor (LAF), relative lens position (RLP), and lens vault (LV). Anterior chamber depth (ACD) and axial length (AL) were also analyzed using A-scan.
The LT was significantly more in all subtypes of PACD (from 4.24 ± 0.84 to 5.02 ± 0.18 mm) than in controls (4.04 ± 0.46 mm; P < 0.01). Similarly, LAF was significantly less among all subtypes of PACD compared to controls (P < 0.001). The RLP, calculated using the formula (ACD + 0.5 LT)/AL × 10, showed no significant difference (P > 0.05) between various study groups. The LV in acute angle-closure glaucoma (AcCG) patients was significantly higher compared to the control population (P < 0.01). Ocular parameters like ACD decreased, whereas LT and LAF increased from normal through primary angle closure (PAC) to primary angle-closure glaucoma (PACG). Logistic regression analysis found a significant association between a decrease in ACD and an increased risk of PACG (P-value was 0.0001) and an increase in LT and LAF with increased risk of PACG (P = 0.040 and P = 0.006, respectively).
Inclusion of lens parameter assessment in the workup of a patient with PACD helps in detection and close monitoring of the progression from suspected to disease state.
通过联合 A 扫描和 A 扫描光学相干断层扫描（AS-OCT）参数，评估晶状体参数在原发性闭角型青光眼（PAC）检测和进展中的作用。
在印度东部的一家三级保健中心进行了一项横断面研究。共纳入了 91 名研究对象，包括病例和对照组。研究的参数包括晶状体厚度（LT）、晶状体轴向因子（LAF）、相对晶状体位置（RLP）和晶状体拱顶（LV）。前房深度（ACD）和眼轴长度（AL）也使用 A 扫描进行分析。
所有类型的 PAC （从 4.24 ± 0.84 至 5.02 ± 0.18mm）的 LT 均显著高于对照组（4.04 ± 0.46mm；P < 0.01）。同样，所有类型的 PAC 的 LAF 均显著低于对照组（P < 0.001）。使用公式（ACD + 0.5 LT）/AL × 10 计算得出的 RLP 在各组研究对象之间无显著差异（P > 0.05）。急性闭角型青光眼（AcCG）患者的 LV 明显高于对照组（P < 0.01）。眼参数如 ACD 减少，而 LT 和 LAF 从正常通过原发性闭角（PAC）增加到原发性闭角型青光眼（PACG）。Logistic 回归分析发现 ACD 减少与 PACG 风险增加之间存在显著关联（P 值为 0.0001），而 LT 和 LAF 增加与 PACG 风险增加之间存在显著关联（P = 0.040 和 P = 0.006）。
在 PAC 患者的检查中纳入晶状体参数评估有助于检测和密切监测从疑似状态到疾病状态的进展。
