Singapore Eye Research Institute and Singapore National Eye Center, Singapore, Republic of Singapore.
Ophthalmology. 2011 Mar;118(3):474-9. doi: 10.1016/j.ophtha.2010.07.025. Epub 2010 Oct 29.
To investigate the association of lens parameters-specifically, lens vault (LV), lens thickness (LT), and lens position (LP)-with angle closure.
Prospective, comparative study.
One hundred two Chinese subjects with angle closure (consisting of primary angle closure, primary angle-closure glaucoma, and previous acute primary angle closure) attending a glaucoma clinic and 176 normal Chinese subjects with open angles and no evidence of glaucoma recruited from an ongoing population-based cross-sectional study.
All participants underwent gonioscopy and anterior-segment optical coherence tomography (AS OCT; Carl Zeiss Meditec, Dublin, CA). Customized software was used to measure LV, defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs, on horizontal AS OCT scans. A-scan biometry (US-800; Nidek Co, Ltd, Tokyo, Japan) was used to measures LT and to calculate LP (defined as anterior chamber depth [ACD] +1/2 LT) and relative LP (RLP; defined as LP/axial length [AL]).
Lens parameters and angle closure.
Significant differences between angle-closure and normal eyes were found for LV (901±265 vs. 316±272 μm; P<0.001), LT (4.20±0.92 vs. 3.90±0.73 mm; P = 0.01), LT-to-AL ratio (0.18±0.04 vs. 0.16±0.03; P<0.001), ACD (2.66±0.37 vs. 2.95±0.37 mm; P<0.001), and AL (22.86±0.93 vs. 23.92±1.37 mm; P<0.001), but no significant differences were found for LP (4.76±0.51 vs. 4.90±0.54 mm; P = 0.34) or RLP (0.21±0.02 vs. 0.20±0.02; P = 0.14). After adjusting for age, gender, ACD, LT, and RLP, increased LV was associated significantly with angle closure (odds ratio [OR], 48.1; 95% confidence interval [CI], 12.8-181.3, comparing lowest to highest quartile), but no association was found for LT (OR, 1.78; 95% CI, 0.76-4.16), LP (OR, 1.94; 95% CI, 0.59-6.31), or RLP (OR, 2.08; 95% CI, 0.66-6.57). There was low correlation between LV and LT (Pearson's correlation coefficient [PCC], 0.17), between LV and RLP (PCC, 0.08), or between LV and LP (PCC, 0.2).
Eyes with angle closure have thicker lenses with greater LV compared with normal eyes. The LV, which represents the anterior portion of the lens, is a novel parameter independently associated with angle closure after adjusting for age, gender, ACD, and LT.
研究晶状体参数（特别是晶状体拱高（LV）、晶状体厚度（LT）和晶状体位置（LP））与闭角型青光眼的关系。
前瞻性、对照研究。
102 例中国闭角型青光眼患者（包括原发性闭角型青光眼、原发性闭角型青光眼和既往急性原发性闭角型青光眼），以及 176 例来自正在进行的基于人群的横断面研究的中国正常开角且无青光眼证据的正常受试者。
所有参与者均接受房角镜检查和眼前段光学相干断层扫描（AS OCT；卡尔蔡司 Meditec，都柏林，加利福尼亚州）。使用定制软件测量水平 AS OCT 扫描上的 LV，LV 定义为晶状体前极与连接 2 个巩膜突的水平线之间的垂直距离。A 扫描生物测量（US-800；日本尼康株式会社）用于测量 LT，并计算 LP（定义为前房深度 [ACD]+1/2 LT）和相对 LP（RLP；定义为 LP/眼轴 [AL]）。
晶状体参数和闭角型青光眼。
与正常眼相比，闭角型青光眼眼的 LV（901±265 对 316±272 μm；P<0.001）、LT（4.20±0.92 对 3.90±0.73 mm；P = 0.01）、LT 与 AL 的比值（0.18±0.04 对 0.16±0.03；P<0.001）、ACD（2.66±0.37 对 2.95±0.37 mm；P<0.001）和 AL（22.86±0.93 对 23.92±1.37 mm；P<0.001）差异均有统计学意义，但 LP（4.76±0.51 对 4.90±0.54 mm；P = 0.34）或 RLP（0.21±0.02 对 0.20±0.02；P = 0.14）差异无统计学意义。在校正年龄、性别、ACD、LT 和 RLP 后，LV 增加与闭角型青光眼显著相关（比值比 [OR]，48.1；95%置信区间 [CI]，12.8-181.3，最低至最高四分位数比较），但 LT 无相关性（OR，1.78；95% CI，0.76-4.16）、LP（OR，1.94；95% CI，0.59-6.31）或 RLP（OR，2.08；95% CI，0.66-6.57）。LV 与 LT 之间的相关性较低（Pearson 相关系数 [PCC]，0.17），LV 与 RLP 之间的相关性较低（PCC，0.08），LV 与 LP 之间的相关性也较低（PCC，0.2）。
与正常眼相比，闭角型青光眼眼的晶状体更厚，LV 更大。LV 代表晶状体的前部，是在调整年龄、性别、ACD 和 LT 后与闭角型青光眼独立相关的新参数。
