He Chentao, Rong Siming, Zhang Piao, Li Ruitao, Li Xiaohong, Li Yan, Wang Lijuan, Zhang Yuhu
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Quant Imaging Med Surg. 2022 Aug;12(8):4226-4238. doi: 10.21037/qims-21-1126.
Processing speed and executive function can be impaired in patients with Parkinson disease (PD). However, the neural factors related to the slowdown in processing speed and dysexecutive function in PD are not completely understood. The objective of this study is to investigate the metabolic changes of the frontal and anterior cingulate cortex (ACC) through the use of H magnetic resonance spectroscopy and to explore the association between cognitive function and metabolic ratios.
In this retrospective case-control study, we conducted neuropsychological assessments of executive function and information processing speed in healthy controls (HCs) and in patients with PD. Chemical information was obtained for the of N-acetyl-aspartate (NAA):creatine (Cr) ratio and the choline-containing compounds (Cho):Cr ratio within the bilateral prefrontal cortex and ACC. Using hierarchical multiple regression analysis, we analyzed the relationship between cognitive function and metabolic ratios in the bilateral prefrontal lobe and ACC in patients with PD.
In all, 59 patients with PD and 30 HCs were recruited. Patients with PD showed worse performance in executive function and processing speed compared with HCs (P<0.001). In patients with PD, the Cho:Cr ratios in the ACC (Z=2.20, P=0.028) and the right prefrontal cortex (=2.16, P=0.034) were significantly increased. The hierarchical multiple regressions in patients with PD showed that the NAA:Cr ratio in the ACC correlated with the Stroop A completion times (P<0.05) and that the NAA:Cr ratio of the right prefrontal cortex correlated with the scores of the Wechsler Adult Intelligence Scale (WAIS)-Digit symbol test (P<0.05).
Information processing speed and executive function are impaired in patients with PD. Neuronal integrity and membrane turnover in the ACC and the right prefrontal cortex may be important factors in the slowdown of the information processing speed in patients with PD.
帕金森病（PD）患者的处理速度和执行功能可能受损。然而，与PD患者处理速度减慢和执行功能障碍相关的神经因素尚未完全明确。本研究的目的是通过使用氢磁共振波谱研究额叶和前扣带回皮质（ACC）的代谢变化，并探讨认知功能与代谢比率之间的关联。
在这项回顾性病例对照研究中，我们对健康对照者（HCs）和PD患者进行了执行功能和信息处理速度的神经心理学评估。获取双侧前额叶皮质和ACC内N-乙酰天门冬氨酸（NAA）与肌酸（Cr）的比率以及含胆碱化合物（Cho）与Cr的比率的化学信息。使用分层多元回归分析，我们分析了PD患者双侧前额叶和ACC中认知功能与代谢比率之间的关系。
共招募了59例PD患者和30例HCs。与HCs相比，PD患者在执行功能和处理速度方面表现更差（P<0.001）。在PD患者中，ACC（Z=2.20，P=0.028）和右侧前额叶皮质（Z=2.16，P=0.034）的Cho:Cr比率显著升高。PD患者的分层多元回归显示，ACC中的NAA:Cr比率与Stroop A完成时间相关（P<0.05），右侧前额叶皮质的NAA:Cr比率与韦氏成人智力量表（WAIS）数字符号测验得分相关（P<0.05）。
PD患者的信息处理速度和执行功能受损。ACC和右侧前额叶皮质的神经元完整性和膜更新可能是PD患者信息处理速度减慢的重要因素。
