Pham James P, Beale Greta, Gorji Mahdieh, Thompson Benjamin, Al-Soufi Suhel, Stone Emily
Department of Thoracic Medicine and Lung Transplantation St Vincent's Hospital Sydney, School of Clinical Medicine, UNSW Medicine and Health St Vincent's Hospital Darlinghurst New South Wales Australia.
Dermatology Department Liverpool Hospital Sydney New South Wales Australia.
Respirol Case Rep. 2022 Jul 30;10(9):e01010. doi: 10.1002/rcr2.1010. eCollection 2022 Sep.
Disseminated primary varicella infection can carry risks of significant morbidity and mortality particularly in immunocompromised populations. Routine, funded childhood vaccination against varicella has significantly reduced associated hospitalization and deaths, however, uptake and efficacy among adults is unknown. We present a case of disseminated primary varicella infection (including rash, pneumonitis, hepatitis and thrombocytopenia) in an immunocompetent patient on long term inhaled corticosteroids for asthma. This case highlights potential risk factors for severe varicella which require further study in adults and raises the need to discuss vaccination in at risk groups including appropriate counselling in those who may be at higher risk.
播散性原发性水痘感染会带来严重发病和死亡风险，尤其是在免疫功能低下人群中。常规的、由政府资助的儿童水痘疫苗接种已显著降低了相关的住院率和死亡率，然而，成人中的疫苗接种率和有效性尚不清楚。我们报告一例免疫功能正常但长期吸入糖皮质激素治疗哮喘的患者发生播散性原发性水痘感染（包括皮疹、肺炎、肝炎和血小板减少症）的病例。该病例突出了成人严重水痘潜在的风险因素，这些因素需要进一步研究，同时也凸显了在高危人群中讨论疫苗接种的必要性，包括对那些可能风险更高的人群进行适当的咨询。
