de Queiroz Marina Vieira Rodrigues, de Medeiros Ana Carolina Tardin Rodrigues, Toledo Sarah Pires, de Abreu Sarmenghi Karina Demoner, de Vasconcellos Vitor Fiorin
Department of Dermatology, Santa Casa de Misericórdia de Vitória Hospital, Vitória, ES, 29025-023, Brazil.
https://orcid.org/0000-0001-5544-458X.
Ecancermedicalscience. 2022 May 16;16:1390. doi: 10.3332/ecancer.2022.1390. eCollection 2022.
Hand-foot syndrome (HFS), or palmar-plantar erythrodysesthesia, is characterised by erythema, oedema and dysesthesia, which can progress to blistering and ulceration. This condition is described as a common adverse effect of the chemotherapeutic agent capecitabine. The study set out to evaluate real-world incidences; assess severity based on clinical criteria, such as local symptoms, dyschromia, erythema, oedema and ulcerations; and associated factors, such as type of solid tumour, chemotherapy regimen, number of cycles, sex, age and Eastern Cooperative Oncology Group Performance Scale of HFS, related to the use of capecitabine. This is a single-centre prospective cohort study carried out jointly by the departments of clinical oncology and dermatology of a university hospital in the southeast of Brazil. The study showed a 34% incidence of HFS, with most cases classified as mild. There was statistical significance in the correlation of the syndrome with sex and performance scores. HFS is the most common and limiting adverse reaction to capecitabine, and causes significant functional and quality impairments in patients with cancer. With this study, we have reinforced the importance of multidisciplinary assessment for early diagnosis and adequate follow-up.
手足综合征（HFS），即掌跖红细胞感觉异常，其特征为红斑、水肿和感觉异常，可发展为水疱和溃疡。这种情况被描述为化疗药物卡培他滨的常见不良反应。该研究旨在评估实际发病率；根据局部症状、色素沉着异常、红斑、水肿和溃疡等临床标准评估严重程度；以及与卡培他滨使用相关的相关因素，如实体瘤类型、化疗方案、周期数、性别、年龄和东部肿瘤协作组HFS表现量表。这是巴西东南部一家大学医院的临床肿瘤学和皮肤科联合开展的单中心前瞻性队列研究。该研究显示HFS的发病率为34%，大多数病例分类为轻度。该综合征与性别和表现评分之间的相关性具有统计学意义。HFS是卡培他滨最常见且具有限制作用的不良反应，会给癌症患者造成明显的功能和生活质量损害。通过这项研究，我们强化了多学科评估对于早期诊断和充分随访的重要性。
