Fan Zixin, Chen Xuejiao, Liu Tianzhi, Yu Qianhui, Song Ziqi, Wang Fei, Li Tuoping
College of Food Science, Shenyang Agricultural University, 120 Dongling Road, Shenhe District, Shenyang, 110866 China.
Food Sci Biotechnol. 2022 Jun 18;31(9):1197-1205. doi: 10.1007/s10068-022-01109-9. eCollection 2022 Aug.
Impacts of pectin oligosaccharide (POS) got from hawthorn fruitage on adiponectin signaling pathway and white adipose metabolism in mice fed with high-fat control. The results showed that POS significantly inhibited the levels of inflammatory cytokines TNF-α and IL-6, and down-regulated expression of CD68. POS dramatically reduced gene expression contents of fatty acid composite concerning enzymes ACC and FAS, as well as TG synthesis-related enzymes SCD-1 and DGAT1 as compared to a high-fat group (HFC). POS dramatically increased expression levels of oxidation-related enzymes of fatty acid ACO, CPT-1, and TG deposition-related enzymes ATGL and HSL as contrast to the high-fat control group. In addition, POS activated adiponectin-mediated AdipoR1/AMPK/PPARα signaling path by upregulating expression levels of AdipoR1, AMPK and PPARα. The results demonstrated that POS can improve lipid metabolism of adipose tissue, and contribute to the creation of functional foods to prevent and treat lipid metabolism disorders.
The online version contains supplementary material available at 10.1007/s10068-022-01109-9.
从山楂果实中提取的果胶寡糖（POS）对高脂饮食小鼠脂联素信号通路及白色脂肪代谢的影响。结果表明，POS显著抑制炎性细胞因子TNF-α和IL-6的水平，并下调CD68的表达。与高脂组（HFC）相比，POS显著降低了脂肪酸合成相关酶ACC和FAS以及甘油三酯合成相关酶SCD-1和DGAT1的基因表达含量。与高脂对照组相比，POS显著提高了脂肪酸氧化相关酶ACO、CPT-1以及甘油三酯沉积相关酶ATGL和HSL的表达水平。此外，POS通过上调AdipoR1、AMPK和PPARα的表达水平激活脂联素介导的AdipoR1/AMPK/PPARα信号通路。结果表明，POS可改善脂肪组织的脂质代谢，有助于开发预防和治疗脂质代谢紊乱的功能性食品。
在线版本包含可在10.1007/s10068-022-01109-9获取的补充材料。
