College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.
Mol Nutr Food Res. 2019 Aug;63(16):e1800773. doi: 10.1002/mnfr.201800773. Epub 2019 Feb 7.
Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic-disorder-associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic-disorder-associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate-related nutrients or drugs.
石榴（Punica granatum Linn）在近几十年来被用于预防和治疗代谢综合征。脂代谢失衡是代谢紊乱的显著特征。体内和体外研究表明，不同石榴部分（果皮、花朵、果汁和种子）的提取物可调节与代谢紊乱相关的疾病中的脂代谢，如动脉粥样硬化、非酒精性脂肪肝和 2 型糖尿病，有助于缓解疾病的发展。减轻氧化应激和炎症反应被认为是石榴提取物调节脂代谢的重要原因。线粒体是脂质氧化的主要细胞部位，与细胞氧化和炎症状态密切相关，可能是石榴提取物作用的靶点。本综述总结了不同石榴部分提取物对代谢紊乱相关疾病中脂代谢的主要影响，并分析了石榴提取物如何发挥作用。此外，它还为石榴相关营养物质或药物的研究和开发提供了重要依据。
