钙补充剂与肽 - 钙螯合物的构效关系：综述
Calcium supplements and structure-activity relationship of peptide-calcium chelates: a review.
作者信息
Zhang Minghui, Liu Kunlun
机构信息
College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001 China.
出版信息
Food Sci Biotechnol. 2022 Jul 16;31(9):1111-1122. doi: 10.1007/s10068-022-01128-6. eCollection 2022 Aug.
Abstract
In recent years, the functional properties of peptides derived from food proteins have attracted considerable interest. Among them, bioactive peptides that can effectively bind metals have application prospects in the improvement of mineral bioavailability, and compensating for the shortcomings of the generally low bioavailability of inorganic mineral supplements. Although a reasonable understanding of structure activity relationship related to the calcium binding of peptides has been gained, physiological connections of peptides as mineral carriers to gastrointestinal uptake needs further research. Hence, this article reviews (1) the development of calcium supplements; (2) inorganic calcium sources and bone calcium; (3) source and acquisition of biologically active peptides; (4) calcium peptide chelation mechanism and structure-activity relationship; and (5) Methods for evaluating calcium bioavailability.
摘要
近年来，源自食物蛋白质的肽的功能特性引起了广泛关注。其中，能够有效结合金属的生物活性肽在提高矿物质生物利用度以及弥补无机矿物质补充剂普遍生物利用度较低的缺点方面具有应用前景。尽管已经对与肽的钙结合相关的构效关系有了合理的认识，但肽作为矿物质载体与胃肠道吸收的生理联系仍需进一步研究。因此，本文综述了：（1）钙补充剂的发展；（2）无机钙源与骨钙；（3）生物活性肽的来源与获取；（4）钙肽螯合机制与构效关系；以及（5）评估钙生物利用度的方法。
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