College of Veterinary Medicine and Biomedical Sciences (CVMBS) (Slinkard, Lana), Department of Microbiology, Immunology, and Pathology (MIP) (Frank), and Department of Environmental and Radiological Health Sciences (ERHS) (Griffin), Colorado State University, Fort Collins, Colorado 80523, USA.
Can Vet J. 2022 Aug;63(8):811-818.
A 4-year-old castrated male golden retriever dog was brought to a veterinary teaching hospital for evaluation of acute progressive paraparesis. Neurological examination indicated a spinal cord lesion between the third thoracic vertebra and third lumbar vertebrae. Magnetic resonance imaging (MRI) revealed an intradural, extra medullary, and/or intramedullary mass centered over the eleventh and twelfth thoracic disc space. The dog underwent cytoreductive surgery and histopathologic analysis diagnosed a nephroblastoma. Following this, the dog underwent multimodal therapy, including multiple surgeries, 2 courses of radiation, and combination chemotherapy. The dog had serial restaging using MRI, computed tomography (CT), and fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography throughout the course of therapy. The dog survived 350 d from date of first presentation until humane euthanasia was elected due to worsening of neurologic status. During postmortem examination, extensive infiltration of the spinal cord by nephroblastoma cells was discovered as well as pulmonary metastatic disease. Key clinical message: Based on the literature search, this is the first case in which surgery, radiation therapy, and chemotherapy were all used for the treatment of canine spinal nephroblastoma. This case report details the aggressive nature of a case of canine spinal nephroblastoma despite multi-modal therapy.
一只 4 岁已去势的雄性金毛寻回猎犬因急性进行性后躯瘫痪被带到兽医教学医院进行评估。神经学检查表明第三胸椎和第三腰椎之间的脊髓病变。磁共振成像（MRI）显示第十一和第十二胸椎椎间盘空间中心存在硬脊膜内、髓外和/或髓内肿块。该犬接受了细胞减少性手术，组织病理学分析诊断为肾母细胞瘤。随后，该犬接受了多模式治疗，包括多次手术、2 个疗程的放疗和联合化疗。在治疗过程中，该犬使用 MRI、计算机断层扫描（CT）和氟-18 氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描进行了连续分期。从首次就诊到因神经状态恶化而选择安乐死，该犬存活了 350 天。在尸检中，发现肾母细胞瘤细胞广泛浸润脊髓以及肺部转移病变。关键临床信息：根据文献检索，这是首例手术、放疗和化疗均用于治疗犬脊髓肾母细胞瘤的病例。本病例报告详细描述了尽管进行了多模式治疗，但犬脊髓肾母细胞瘤的侵袭性。
